Journal of Bone and Mineral Metabolism

, Volume 28, Issue 2, pp 117–130

Vitamin D and the skin

Review Article

DOI: 10.1007/s00774-009-0153-8

Cite this article as:
Bikle, D.D. J Bone Miner Metab (2010) 28: 117. doi:10.1007/s00774-009-0153-8


The keratinocytes of the skin are unique in being not only the primary source of vitamin D for the body, but also possessing the enzymatic machinery to metabolize vitamin D to active metabolites [in particular, 1,25 dihydroxyvitamin D (1,25(OH)2D)] and the vitamin D receptor (VDR) that enables the keratinocytes to respond to the 1,25(OH)2D they produce. Numerous functions of the skin are regulated by vitamin D and/or its receptor: these include inhibition of proliferation, stimulation of differentiation including formation of the permeability barrier, promotion of innate immunity, regulation of the hair follicle cycle, and suppression of tumor formation. Regulation of these actions is exerted by a number of different coregulators including the coactivators DRIP and SRC, a less well known inhibitor, hairless, and β-catenin. Different coregulators appear to be involved in different VDR-regulated functions. This review examines the various functions of vitamin D and its receptor, and to the extent known explores the mechanisms by which these functions are regulated.


Vitamin DEpidermisHair follicleDifferentiationCarcinogenesis

Copyright information

© The Japanese Society for Bone and Mineral Research and Springer 2010

Authors and Affiliations

  1. 1.Veterans Affairs Medical CenterUniversity of CaliforniaSan FranciscoUSA