Journal of Bone and Mineral Metabolism

, Volume 26, Issue 4, pp 358–365

Genotypes and clinical aspects associated with bone mineral density in Argentine postmenopausal women

  • Adriana Pérez
  • María Ulla
  • Beatriz García
  • María Lavezzo
  • Eliana Elías
  • Miriam Binci
  • María Rivoira
  • Viviana Centeno
  • Arturo Alisio
  • Nori Tolosa de Talamoni
Original Article

DOI: 10.1007/s00774-007-0840-2

Cite this article as:
Pérez, A., Ulla, M., García, B. et al. J Bone Miner Metab (2008) 26: 358. doi:10.1007/s00774-007-0840-2

Abstract

The aim of this study was to determine genotypes and clinical aspects associated with bone mineral density (BMD) in postmenopausal women from Córdoba, Argentina. Polymorphisms were assessed by RFLP-PCR technique using BsmI and FokI for vitamin D receptor gene (VDR) and XbaI and PvuII for estrogen receptor-α gene (ERα) as restrictases. Sixty-eight healthy, 54 osteopenic, and 64 osteoporotic postmenopausal women were recruited. Femoral neck and lumbar spine BMD were inversely correlated with age in the entire analyzed population. Height was lower in osteopenic and osteoporotic women as compared to healthy women (P < 0.05). Weight and body mass index (BMI) were the lowest in osteoporotic women (P < 0.01 versus healthy group). Serum procollagen type I Nterminal propeptide (PINP) was higher in osteoporotic women as compared to the other groups. Distribution of VDR and ERα genotypes was similar in the three groups. Genotype bb (VDR) was associated with low values of lumbar BMD in the healthy group (P < 0.05 versus genotype Bb), and with low values of femoral BMD (P < 0.05 versus genotype BB) in osteoporotic women. BB*Pp interaction was associated with the highest femoral neck BMD (P < 0.05), whereas the bb*xx interaction was associated with the lowest femoral neck BMD in the total population analyzed (P < 0.05). In conclusion, parameters such as age, height, weight, BMI, serum PINP, VDR genotypes, and interactions between VDR and ERá genotypes could be useful to predict a decrease in BMD in Argentine postmenopausal women.

Key words

VDRERbone mineral densityosteoporosispostmenopausal women

Copyright information

© Springer Japan 2008

Authors and Affiliations

  • Adriana Pérez
    • 1
  • María Ulla
    • 2
  • Beatriz García
    • 1
  • María Lavezzo
    • 1
  • Eliana Elías
    • 1
  • Miriam Binci
    • 1
  • María Rivoira
    • 2
  • Viviana Centeno
    • 1
  • Arturo Alisio
    • 1
  • Nori Tolosa de Talamoni
    • 1
  1. 1.Laboratorio de Metabolismo Fosfocálcico y Vitamina D “Dr. Fernando Cañas,” Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias MédicasUniversidad Nacional de CórdobaCórdobaArgentina
  2. 2.Centro Privado de EndocrinologíaOsteología y MetabolismoCórdobaArgentina