Journal of Bone and Mineral Metabolism

, Volume 25, Issue 5, pp 302–309

Factors affecting long-term compliance of osteoporotic patients with bisphosphonate treatment and QOL assessment in actual practice: alendronate and risedronate


    • Maruzen Pharmacy
    • Kyoto Pharmaceutical University
  • Shiro Koto
    • Koto OrthopedicInternal Medicine Clinic
  • Nobuhiro Ozawa
    • Koto OrthopedicInternal Medicine Clinic
  • Chie Urao
    • Maruzen Pharmacy
  • Yumiko Suzuki
    • Maruzen Pharmacy
  • Eri Akasaka
    • Maruzen Pharmacy
  • Kae Yanagimoto
    • Maruzen Pharmacy
  • Kazumi Sakota
    • Maruzen Pharmacy

DOI: 10.1007/s00774-007-0768-6

Cite this article as:
Kamatari, M., Koto, S., Ozawa, N. et al. J Bone Miner Metab (2007) 25: 302. doi:10.1007/s00774-007-0768-6


The aim of our study was to examine compliance with a daily dose of 5 mg alendronate (ALN) and 2.5 mg risedronate (RDN) in actual practice, and to determine the causes of noncompliance through a questionnaire. In addition, we studied the quality of life (QOL) of patients through another disease-related questionnaire. The overall compliance rate remained at approximately 40% one year after the initial dose. The rates did not differ significantly between the ALN group (783 patients) and the RDN group (491 patients). The compliances in the female group and the rheumatism group were better than in the male group and the nonrheumatism group. From the questionnaire, 36% of noncompliant patients showed adverse effects (AEs), and the other noncompliant patients stopped the medication in spite of having no AEs. A logistic regression analysis of factors that might have affected long-term compliance included AEs, an understanding of the disease, the method of ingestion, visiting medical facilities, the shape of the tablet, the cost of the drug, and the explanation of the doctor or pharmacist. This analysis showed that noncompliance occurred mainly due to AEs, the inconvenience of visiting a medical facility, unusual methods of ingestion, and a poor understanding of the disease. According to the results of the questionnaire for QOL assessment, the patients who continued the medication for more than 1 year had improved scores for pain in both the ALN and RDN groups. Osteoporotic treatment needs long-term patient compliance. To improve compliance, it is very important that doctors and pharmacists ensure that patients understand the purpose of this therapy.

Key words

compliancepersistenceosteoporosisbisphosphonatequality of life

Copyright information

© Springer-Verlag Tokyo 2007