Journal of Bone and Mineral Metabolism

, Volume 25, Issue 4, pp 253–258

Association of a single nucleotide polymorphism in the WISP1 gene with spinal osteoarthritis in postmenopausal Japanese women

  • Tomohiko Urano
  • Ken'ichiro Narusawa
  • Masataka Shiraki
  • Takahiko Usui
  • Noriko Sasaki
  • Takayuki Hosoi
  • Yasuyoshi Ouchi
  • Toshitaka Nakamura
  • Satoshi Inoue
ORIGINAL ARTICLE

DOI: 10.1007/s00774-007-0757-9

Cite this article as:
Urano, T., Narusawa, K., Shiraki, M. et al. J Bone Miner Metab (2007) 25: 253. doi:10.1007/s00774-007-0757-9

Abstract

The Wnt-β-catenin signaling pathway that regulates bone density is also involved in cartilage development and homeostasis in vivo. Here, we assumed that genetic variation in Wnt-β-catenin signaling genes can affect the pathogenesis of cartilage related diseases, such as osteoarthritis. Wnt-1-induced secreted protein 1 (WISP1) is a target of the Wnt pathway and directly regulated by β-catenin. In the present study, we analyzed the association of a single nucleotide polymorphism (SNP) in the WISP1 3′-UTR region with the development of radiographically observable osteoarthritis of the spine. For this purpose, we evaluated the presence of osteophytes, endplate sclerosis, and narrowing of disc spaces in 304 postmenopausal Japanese women. We compared those who carried the G allele (GG or GA, n = 184) with those who did not (AA, n = 120). We found that the subjects without the G allele (AA) were significantly over-represented in the subjects having higher endplate sclerosis score (P = 0.0069; odds ratio, 2.91; 95% confidence interval, 1.34–6.30 by logistic regression analysis). On the other hand, the occurrence of disc narrowing and osteophyte formation did not significantly differ between those with and without at least one G allele. Thus, we suggest that a genetic variation in the WISP1 gene locus is associated with spinal osteoarthritis, in line with the involvement of the Wnt-β-catenin-regulated gene in bone and cartilage metabolism.

Key words

single nucleotide polymorphism (SNP)Wnt-β-catenin signalingWISP1osteoarthritisendplate sclerosis

Copyright information

© Springer-Verlag Tokyo 2007

Authors and Affiliations

  • Tomohiko Urano
    • 1
    • 2
  • Ken'ichiro Narusawa
    • 3
  • Masataka Shiraki
    • 4
  • Takahiko Usui
    • 1
  • Noriko Sasaki
    • 1
  • Takayuki Hosoi
    • 5
  • Yasuyoshi Ouchi
    • 1
  • Toshitaka Nakamura
    • 3
  • Satoshi Inoue
    • 1
    • 6
  1. 1.Department of Geriatric MedicineGraduate School of Medicine, The University of TokyoTokyoJapan
  2. 2.Department of Coca-Cola Anti-Aging MedicineGraduate School of Medicine, The University of TokyoTokyoJapan
  3. 3.Department of Orthopedic SurgeryUniversity of Occupational and Environmental Health, School of MedicineKitakyushuJapan
  4. 4.Research Institute and Practice for Involutional DiseasesNaganoJapan
  5. 5.Department of Advanced MedicineNational Center for Geriatrics and GerontologyAichiJapan
  6. 6.Research Center for Genomic MedicineSaitama Medical SchoolSaitamaJapan