Journal of Bone and Mineral Metabolism

, Volume 23, Issue 6, pp 506–513

Effects of a low sodium diet on bone metabolism

Authors

    • Department of MedicineUniversity of Tennessee Health Science Center
  • Karen D. Barrow
    • Department of MedicineUniversity of Tennessee Health Science Center
  • Andrew J. Bush
    • Department of Preventive MedicineUniversity of Tennessee Health Science Center
  • M. David Boatright
    • Department of MedicineUniversity of Tennessee Health Science Center
  • Jean A. Michelson
    • General Clinical Research CenterUniversity of Tennessee Health Science Center
  • Kathleen A. Pitts
    • General Clinical Research CenterUniversity of Tennessee Health Science Center
  • Victorina N. Pintea
    • Department of PhysiologyUniversity of Tennessee Health Science Center
  • Andrew H. Kang
    • Department of MedicineUniversity of Tennessee Health Science Center
  • Mitchell A. Watsky
    • Department of PhysiologyUniversity of Tennessee Health Science Center
ORIGINAL ARTICLE

DOI: 10.1007/s00774-005-0621-8

Cite this article as:
Carbone, L., Barrow, K., Bush, A. et al. J Bone Miner Metab (2005) 23: 506. doi:10.1007/s00774-005-0621-8

Abstract

Osteoporosis is a serious public health problem, and dietary interventions may potentially be helpful in preventing this disorder. The purpose of this study was to determine the effects of a low sodium diet on bone metabolism in postmenopausal women. This was a longitudinal study to determine the effects of a low sodium (2-g/day) diet on bone. Forty postmenopausal African–American and Caucasian women were enrolled in a 2-g/day sodium diet for 6 months. Sodium and calcium excretion, bone turnover, and calcitropic hormones (intact parathyroid hormone (PTH) and 1,25 dihydroxyvitamin D) were measured before and 6 months after the intervention. In women who had baseline sodium excretions equal to or greater than the average sodium intake in the United States (≥3.4 g/day), the low sodium diet resulted in significant decreases in sodium excretion (P = 0.01), in calcium excretion (P = 0.01), and in a biomarker of bone turnover, aminoterminal propeptide of type I collagen (P = 0.04). However, there were no significant changes in calcitropic hormones, including intact PTH (P = 0.97) or 1,25 dihydroxyvitamin D (P = 0.49) with the low sodium diet. These findings suggest that in postmenopausal women with sodium intakes ≥3.4 g/day, a low sodium diet may have benefits for skeletal health.

Key words

DietSodiumBone

Copyright information

© Springer-Verlag Tokyo 2005