Journal of Bone and Mineral Metabolism

, Volume 23, Issue 3, pp 191–199

Syndecan-3: a cell-surface heparan sulfate proteoglycan important for chondrocyte proliferation and function during limb skeletogenesis

  • Maurizio Pacifici
  • Tsuyoshi Shimo
  • Chiara Gentili
  • Thorsten Kirsch
  • Theresa A. Freeman
  • Motomi Enomoto-Iwamoto
  • Masahiro Iwamoto
  • Eiki Koyama
REVIEW ARTICLE

DOI: 10.1007/s00774-004-0584-1

Cite this article as:
Pacifici, M., Shimo, T., Gentili, C. et al. J Bone Miner Metab (2005) 23: 191. doi:10.1007/s00774-004-0584-1

Abstract

Syndecans are single-pass integral membrane components that serve as co-receptors for growth factors and cytokines and can elicit signal transduction via their cytoplasmic tails. We review here previous studies from our groups on syndecan-3 biology and function in the growth plates of developing long bones in chick and mouse embryos. Gain- and loss-of-function data indicate that syndecan-3 has important roles in restricting mitotic activity to the proliferative zone of growth plate and may do so in close cooperation and interaction with the signaling molecule Indian hedgehog (IHH). Biochemical and protein-modeling data suggest a dimeric/oligomeric syndecan-3 configuration on the chondrocyte’s cell surface. Analyses of embryos misexpressing syndecan-3 or lacking IHH provide further clues on syndecan-3/IHH interdependence and interrelationships. The data and the conclusions reached provide insights into mechanisms fine-tuning chondrocyte proliferation, maturation, and function in the developing and growing skeleton and into how abnormalities in these fundamental mechanisms may subtend human congenital pathologies, including osteochondromas in hereditary multiple exostoses syndrome.

Key words

Syndecan-3 Chondrocyte proliferation Indian hedgehog Growth plate Chondrocyte maturation Limb skeletogenesis 

Copyright information

© Springer-Verlag Tokyo 2005

Authors and Affiliations

  • Maurizio Pacifici
    • 1
  • Tsuyoshi Shimo
    • 2
  • Chiara Gentili
    • 3
  • Thorsten Kirsch
    • 4
  • Theresa A. Freeman
    • 1
  • Motomi Enomoto-Iwamoto
    • 1
  • Masahiro Iwamoto
    • 1
  • Eiki Koyama
    • 1
  1. 1.Department of Orthopaedic SurgeryThomas Jefferson University College of MedicinePhiladelphiaUSA
  2. 2.Department of Oral and Maxillofacial SurgeryOkayama University Graduate School of Medicine and DentistryOkayamaJapan
  3. 3.Medicina RigenerativaIstituto Nazionale Ricerca sul CancroGenovaItaly
  4. 4.Department of Orthopaedic SurgeryUniversity of MarylandBaltimoreUSA

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