Journal of Bone and Mineral Metabolism

, Volume 22, Issue 4, pp 341–345

Association of a single-nucleotide polymorphism in low-density lipoprotein receptor-related protein 5 gene with bone mineral density

Authors

  • Tomohiko Urano
    • Department of Geriatric Medicine, Graduate School of MedicineThe University of Tokyo
  • Masataka Shiraki
    • Research Institute and Practice for Involutional Diseases
  • Yoichi Ezura
    • Department of Molecular Biology, Institute of GerontologyNippon Medical School
  • Masayo Fujita
    • Department of Geriatric Medicine, Graduate School of MedicineThe University of Tokyo
  • Emiko Sekine
    • Department of Geriatric Medicine, Graduate School of MedicineThe University of Tokyo
  • Shinjiro Hoshino
    • Department of Geriatric Medicine, Graduate School of MedicineThe University of Tokyo
  • Takayuki Hosoi
    • Tokyo Metropolitan Geriatric Medical Center
  • Hajime Orimo
    • Health Science University
  • Mitsuru Emi
    • Department of Molecular Biology, Institute of GerontologyNippon Medical School
  • Yasuyoshi Ouchi
    • Department of Geriatric Medicine, Graduate School of MedicineThe University of Tokyo
    • Department of Geriatric Medicine, Graduate School of MedicineThe University of Tokyo
    • Research Center for Genomic MedicineSaitama Medical School
Article

DOI: 10.1007/s00774-003-0492-9

Cite this article as:
Urano, T., Shiraki, M., Ezura, Y. et al. J Bone Miner Metab (2004) 22: 341. doi:10.1007/s00774-003-0492-9

Abstract

Low-density lipoprotein receptor-related protein 5 (LRP5) is an important regulator of osteoblast growth and differentiation, affecting peak bone mass in vertebrates. Here, we analyzed whether the LRP5 gene was involved in the etiology of postmenopausal osteoporosis, using association analysis between bone mineral density (BMD) and an LRP5 gene single-nucleotide polymorphism (SNP). Association of an SNP in the LRP5 gene at IVS17-1677C > A (intron 17) with BMD was examined in 308 postmenopausal Japanese women (65.2 ± 9.6 years; mean ± SD). The subjects bearing at least one variant A allele (CA + AA; n = 142) had significantly lower Z scores for total body and lumbar BMD than the subjects with no A allele (CC; n = 166) (total body, 0.08 ± 1.09 versus 0.50 ± 1.03; P = 0.0022; lumbar spine, −0.42 ± 1.43 versus −0.02 ± 1.42; P = 0.013). These findings suggest that the LRP5 gene is a candidate for the genetic determinants of BMD in postmenopausal women, and this SNP could be useful as a genetic marker for predicting the risk of osteoporosis.

Key words

wnt LRP5 osteoporosis bone mineral density polymorphism

Copyright information

© Springer-Verlag Tokyo 2004