Journal of Bone and Mineral Metabolism

, Volume 22, Issue 4, pp 341–345

Association of a single-nucleotide polymorphism in low-density lipoprotein receptor-related protein 5 gene with bone mineral density

  • Tomohiko Urano
  • Masataka Shiraki
  • Yoichi Ezura
  • Masayo Fujita
  • Emiko Sekine
  • Shinjiro Hoshino
  • Takayuki Hosoi
  • Hajime Orimo
  • Mitsuru Emi
  • Yasuyoshi Ouchi
  • Satoshi Inoue
Article

DOI: 10.1007/s00774-003-0492-9

Cite this article as:
Urano, T., Shiraki, M., Ezura, Y. et al. J Bone Miner Metab (2004) 22: 341. doi:10.1007/s00774-003-0492-9

Abstract

Low-density lipoprotein receptor-related protein 5 (LRP5) is an important regulator of osteoblast growth and differentiation, affecting peak bone mass in vertebrates. Here, we analyzed whether the LRP5 gene was involved in the etiology of postmenopausal osteoporosis, using association analysis between bone mineral density (BMD) and an LRP5 gene single-nucleotide polymorphism (SNP). Association of an SNP in the LRP5 gene at IVS17-1677C > A (intron 17) with BMD was examined in 308 postmenopausal Japanese women (65.2 ± 9.6 years; mean ± SD). The subjects bearing at least one variant A allele (CA + AA; n = 142) had significantly lower Z scores for total body and lumbar BMD than the subjects with no A allele (CC; n = 166) (total body, 0.08 ± 1.09 versus 0.50 ± 1.03; P = 0.0022; lumbar spine, −0.42 ± 1.43 versus −0.02 ± 1.42; P = 0.013). These findings suggest that the LRP5 gene is a candidate for the genetic determinants of BMD in postmenopausal women, and this SNP could be useful as a genetic marker for predicting the risk of osteoporosis.

Key words

wnt LRP5 osteoporosis bone mineral density polymorphism 

Copyright information

© Springer-Verlag Tokyo 2004

Authors and Affiliations

  • Tomohiko Urano
    • 1
  • Masataka Shiraki
    • 2
  • Yoichi Ezura
    • 3
  • Masayo Fujita
    • 1
  • Emiko Sekine
    • 1
  • Shinjiro Hoshino
    • 1
  • Takayuki Hosoi
    • 4
  • Hajime Orimo
    • 5
  • Mitsuru Emi
    • 3
  • Yasuyoshi Ouchi
    • 1
  • Satoshi Inoue
    • 1
    • 6
  1. 1.Department of Geriatric Medicine, Graduate School of MedicineThe University of TokyoTokyoJapan
  2. 2.Research Institute and Practice for Involutional DiseasesNaganoJapan
  3. 3.Department of Molecular Biology, Institute of GerontologyNippon Medical SchoolKawasakiJapan
  4. 4.Tokyo Metropolitan Geriatric Medical CenterTokyoJapan
  5. 5.Health Science UniversityYamanashiJapan
  6. 6.Research Center for Genomic MedicineSaitama Medical SchoolSaitamaJapan

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