Accreditation and Quality Assurance

, Volume 4, Issue 8, pp 374–377

The synthesis and characterization of pure substance reference materials for forensic, agricultural and drugs-in-sport analysis

  • Bruce Noble

DOI: 10.1007/s007690050388

Cite this article as:
Noble, B. Accred Qual Assur (1999) 4: 374. doi:10.1007/s007690050388


 The paper reports work on the synthesis, purification and certification of pure substance (organic) reference materials as conducted within the National Analytical Reference Laboratory (NARL). Areas of interest include illicit drugs, agricultural and veterinary chemicals, and steroids and steroid metabolites and their deuterates. The discussion covers the prioritization of work requirements, procedures for synthesis and production, quality assurance, characterization, homogeneity, storage and stability testing, and certification of materials. Future plans for establishing traceability are also discussed.

Key words  Pure substance reference materials Characterization Certification Quality assurance and control Purification 

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • Bruce Noble
    • 1
  1. 1.Pure Substance Reference Materials Team, National Analytical Reference Laboratory, P. O. Box 385 Pymble, NSW 2073, Australia Tel.: +61-2-9449-0111 Fax: +61-2-9449-1653 e-mail:

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