Amino Acids

, Volume 21, Issue 2, pp 211–219

Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4

Authors

  • R. Hammermann
    • Institute of Pharmacology and Toxicology, Rheinische Friedrich-Wilhelms-Universität, Bonn, Federal Republic of Germany
  • G. Brunn
    • Institute of Pharmacology and Toxicology, Rheinische Friedrich-Wilhelms-Universität, Bonn, Federal Republic of Germany
  • K. Racké
    • Institute of Pharmacology and Toxicology, Rheinische Friedrich-Wilhelms-Universität, Bonn, Federal Republic of Germany
Short Communication

DOI: 10.1007/s007260170029

Cite this article as:
Hammermann, R., Brunn, G. & Racké, K. Amino Acids (2001) 21: 211. doi:10.1007/s007260170029

Summary.

By screening nucleotide databases, sequences containing the complete genes of the human cationic amino acid transporters (hCATs) 1, 2 and 4 were identified. Analysis of the genomic organization revealed that hCAT-2 consists of 12 translated exons and most likely of 2 untranslated exons. The splice variants hCAT-2A and hCAT-2B use exon 7 and 6, respectively. The hCAT-2 gene structure is closely related to the structure of hCAT-1, suggesting that they belong to a common gene family. hCAT-4 consists of only 4 translated exons and 3 short introns. Exons of identical size and highly homologous to exon 3 of hCAT-4 are present in hCAT-1 and hCAT-2.

Keywords: Cationic amino acidsHuman cationic amino acid transporterSolute carrier familyGenomic organizationExon-intron structure

Copyright information

© Springer-Verlag Wien 2001