Amino Acids

, Volume 19, Issue 1, pp 167–172

NMDA channel blockers: memantine and amino-aklylcyclohexanes –In vivo characterization

Authors

  • W. Danysz
    • Department of Pharmacological Research, Merz+Co, Frankfurt/Main, Federal Republic of Germany
  • C. G. Parsons
    • Department of Pharmacological Research, Merz+Co, Frankfurt/Main, Federal Republic of Germany
  • G. Quack
    • Department of Pharmacological Research, Merz+Co, Frankfurt/Main, Federal Republic of Germany
Review Article

DOI: 10.1007/s007260070045

Cite this article as:
Danysz, W., Parsons, C. & Quack, G. Amino Acids (2000) 19: 167. doi:10.1007/s007260070045

Summary.

The previous overviews provided the basis for better therapeutic efficacy/tolerability of low to moderate affinity NMDA channel blockers. This prediction finds support in in vitro studies comparing protective and plasticity impairing effects (therapeutic vs. side-effect) of memantine and (+)MK-801. In fact it turned out that memantine had a far better therapeutic index. But can it be confirmed in the in vivo situation?

Keywords: Amino acids NMDA Channel blockers Memantine

Copyright information

© Springer-Verlag Wien 2000