NMDA channel blockers: memantine and amino-aklylcyclohexanes –In vivo characterization
- Cite this article as:
- Danysz, W., Parsons, C. & Quack, G. Amino Acids (2000) 19: 167. doi:10.1007/s007260070045
The previous overviews provided the basis for better therapeutic efficacy/tolerability of low to moderate affinity NMDA channel blockers. This prediction finds support in in vitro studies comparing protective and plasticity impairing effects (therapeutic vs. side-effect) of memantine and (+)MK-801. In fact it turned out that memantine had a far better therapeutic index. But can it be confirmed in the in vivo situation?