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Effect of the external electric field on selected tripeptides

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Abstract

The effect of external electric field (EEF) of 5.14, 25.70, and 51.40 MV/cm upon Cys-Asn-Ser, Glu-Arg-Leu, Glu-Cys-Glc, Ser-Asp-Leu, Ser-Glu-Met tripeptide inner salts was simulated involving HyperChem 8.0 software together with the AM1 method for optimization of the molecules’ conformation. The reaction to EEF is diverse and specific to particular peptides. EEF stimulated an increase in the positive charge density on the hydrogen atoms of the N+H3, peptide bond NH, NH2, and COOH groups as well decrease in the negative charge density on the oxygen atoms of the peptide bond carbonyl groups. Thus, EEF could control behavior and action of tripeptides, such as an increase in their catalytic activity.

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Conflict of interest

The authors of the submitted text (Effect of external electric field on selected tripeptides) know nothing about potential conflict of interest between us and known to us researchers involved in the peptide study.

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Authors and Affiliations

  1. Department of Chemistry and Physics, University of Agriculture, Mickiewicz Ave., 21, 30159, Kraków, Poland

    Józef Mazurkiewicz

  2. Department of Inorganic Technology and Environmental Biotechnology, Cracow University of Technology, Warszawska Street 24, 30-155, Kraków, Poland

    Henryk Kołoczek

  3. Krakow College of Health Promotion, Krowoderska Street, 73, 31158, Krakow, Poland

    Piotr Tomasik

Authors
  1. Józef Mazurkiewicz
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  2. Henryk Kołoczek
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  3. Piotr Tomasik
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Correspondence to Piotr Tomasik.

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Handling Editor: M. S. Palma.

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Mazurkiewicz, J., Kołoczek, H. & Tomasik, P. Effect of the external electric field on selected tripeptides. Amino Acids 47, 1399–1408 (2015). https://doi.org/10.1007/s00726-015-1971-8

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  • DOI: https://doi.org/10.1007/s00726-015-1971-8

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