Amino Acids

, Volume 42, Issue 4, pp 1205–1220

The pathogenic role of Maillard reaction in the aging eye

  • Ram H. Nagaraj
  • Mikhail Linetsky
  • Alan W. Stitt
Review Article

DOI: 10.1007/s00726-010-0778-x

Cite this article as:
Nagaraj, R.H., Linetsky, M. & Stitt, A.W. Amino Acids (2012) 42: 1205. doi:10.1007/s00726-010-0778-x

Abstract

The proteins of the human eye are highly susceptible to the formation of advanced glycation end products (AGEs) from the reaction of sugars and carbonyl compounds. AGEs progressively accumulate in the aging lens and retina and accumulate at a higher rate in diseases that adversely affect vision such as, cataract, diabetic retinopathy and age-related macular degeneration. In the lens AGEs induce irreversible changes in structural proteins, which lead to lens protein aggregation and formation of high-molecular-weight aggregates that scatter light and impede vision. In the retina AGEs modify intra- and extracellular proteins that lead to an increase in oxidative stress and formation of pro-inflammatory cytokines, which promote vascular dysfunction. This review outlines recent advances in AGE research focusing on the mechanisms of their formation and their role in cataract and pathologies of the retina. The therapeutic action and pharmacological strategies of anti-AGE agents that can inhibit or prevent AGE formation in the eye are also discussed.

Keywords

Lens Retina Aging Diabetes Cataract Diabetic retinopathy Age-related macular degeneration 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Ram H. Nagaraj
    • 1
  • Mikhail Linetsky
    • 1
  • Alan W. Stitt
    • 2
  1. 1.Department of Ophthalmology and Visual SciencesCase Western Reserve UniversityClevelandUSA
  2. 2.Centre for Vision and Vascular ScienceQueen’s University BelfastNorthern IrelandUK

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