Amino Acids

, Volume 40, Issue 1, pp 15–28

Venomics: a new paradigm for natural products-based drug discovery

  • Irina Vetter
  • Jasmine L. Davis
  • Lachlan D. Rash
  • Raveendra Anangi
  • Mehdi Mobli
  • Paul F. Alewood
  • Richard J. Lewis
  • Glenn F. King
Review Article

DOI: 10.1007/s00726-010-0516-4

Cite this article as:
Vetter, I., Davis, J.L., Rash, L.D. et al. Amino Acids (2011) 40: 15. doi:10.1007/s00726-010-0516-4

Abstract

The remarkable potency and pharmacological diversity of animal venoms has made them an increasingly valuable source of lead molecules for drug and insecticide discovery. Nevertheless, most of the chemical diversity encoded within these venoms remains uncharacterized, despite decades of research, in part because of the small quantities of venom available. However, recent advances in the miniaturization of bioassays and improvements in the sensitivity of mass spectrometry and NMR spectroscopy have allowed unprecedented access to the molecular diversity of animal venoms. Here, we discuss these technological developments in the context of establishing a high-throughput pipeline for venoms-based drug discovery.

Keywords

Drug discoveryAnimal venomsVenomicsVenom peptidesNatural products

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Irina Vetter
    • 1
  • Jasmine L. Davis
    • 1
  • Lachlan D. Rash
    • 1
  • Raveendra Anangi
    • 1
  • Mehdi Mobli
    • 1
  • Paul F. Alewood
    • 1
  • Richard J. Lewis
    • 1
  • Glenn F. King
    • 1
  1. 1.Institute for Molecular BioscienceThe University of QueenslandSt. LuciaAustralia