Amino Acids

, Volume 40, Issue 1, pp 15–28

Venomics: a new paradigm for natural products-based drug discovery

Authors

  • Irina Vetter
    • Institute for Molecular BioscienceThe University of Queensland
  • Jasmine L. Davis
    • Institute for Molecular BioscienceThe University of Queensland
  • Lachlan D. Rash
    • Institute for Molecular BioscienceThe University of Queensland
  • Raveendra Anangi
    • Institute for Molecular BioscienceThe University of Queensland
  • Mehdi Mobli
    • Institute for Molecular BioscienceThe University of Queensland
  • Paul F. Alewood
    • Institute for Molecular BioscienceThe University of Queensland
  • Richard J. Lewis
    • Institute for Molecular BioscienceThe University of Queensland
    • Institute for Molecular BioscienceThe University of Queensland
Review Article

DOI: 10.1007/s00726-010-0516-4

Cite this article as:
Vetter, I., Davis, J.L., Rash, L.D. et al. Amino Acids (2011) 40: 15. doi:10.1007/s00726-010-0516-4

Abstract

The remarkable potency and pharmacological diversity of animal venoms has made them an increasingly valuable source of lead molecules for drug and insecticide discovery. Nevertheless, most of the chemical diversity encoded within these venoms remains uncharacterized, despite decades of research, in part because of the small quantities of venom available. However, recent advances in the miniaturization of bioassays and improvements in the sensitivity of mass spectrometry and NMR spectroscopy have allowed unprecedented access to the molecular diversity of animal venoms. Here, we discuss these technological developments in the context of establishing a high-throughput pipeline for venoms-based drug discovery.

Keywords

Drug discovery Animal venoms Venomics Venom peptides Natural products

Copyright information

© Springer-Verlag 2010