Amino Acids

, Volume 36, Issue 4, pp 659–670

Transglutaminase 2 cross-linking of matrix proteins: biological significance and medical applications

Review Article

DOI: 10.1007/s00726-008-0190-y

Cite this article as:
Collighan, R.J. & Griffin, M. Amino Acids (2009) 36: 659. doi:10.1007/s00726-008-0190-y


This review summarises the functions of the enzyme tissue transglutaminase (TG2) in the extracellular matrix (ECM) both as a matrix stabiliser through its protein cross-linking activity and as an important cell adhesion protein involved in cell survival. The contribution of extracellular TG2 to the pathology of important diseases such as cancer and fibrosis are discussed with a view to the potential importance of TG2 as a therapeutic target. The medical applications of TG2 are further expanded by detailing the use of transglutaminase cross-linking in the development of novel biocompatible biomaterials for use in soft and hard tissue repair.


Tissue transglutaminaseTG2BiomaterialsExtracellular matrixCross-linking

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.School of Life and Health SciencesAston UniversityBirminghamUK