Amino Acids

, 34:517

Transport of amino acids through the placenta and their role

Review Article

DOI: 10.1007/s00726-007-0006-5

Cite this article as:
Grillo, M.A., Lanza, A. & Colombatto, S. Amino Acids (2008) 34: 517. doi:10.1007/s00726-007-0006-5


Amino acids are transported across the human placenta mediated by transporter proteins that differ in structure, mechanism and substrate specificity. Some of them are Na+-dependent systems, whereas others are Na+-independent. Among these there are transporters composed of a heavy chain, a glycoprotein, and a light chain. Moreover, they can be differently distributed in the two membranes forming the syncytiotrophoblast. The transport mechanisms involved and their regulation are only partially known. In the placenta itself, part of the amino acids is metabolized to form other compounds important for the fetus. This occurs for instance for arginine, which gives rise to polyamines and to NO. Interconversion occurs among few other amino acids Transport is altered in pregnancy complications, such as restricted fetal growth.


Transport systems Glycoprotein associated transporters Indoleamino 2,3-dioxygenase Polyamines 

Copyright information

© Springer 2007

Authors and Affiliations

  1. 1.Dipartimento di Medicina e Oncologia Sperimentale, Sezione di BiochimicaUniversità di TorinoTorinoItaly

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