Amino Acids

, Volume 30, Issue 3, pp 279–289

The absorption of orally supplied β-alanine and its effect on muscle carnosine synthesis in human vastus lateralis

Authors

  • R. C. Harris
    • School of Sports, Exercise and Health Sciences, University College Chichester
  • M. J. Tallon
    • School of Sports, Exercise and Health Sciences, University College Chichester
  • M. Dunnett
    • School of Sports, Exercise and Health Sciences, University College Chichester
  • L. Boobis
    • Sunderland Royal Hospital
  • J. Coakley
    • Intensive Care UnitHomerton Hospital
  • H. J. Kim
    • Human Exercise Physiology, Korea National Sport University
  • J. L. Fallowfield
    • School of Sports, Exercise and Health Sciences, University College Chichester
  • C. A. Hill
    • School of Sports, Exercise and Health Sciences, University College Chichester
  • C. Sale
    • School of Sports, Exercise and Health Sciences, University College Chichester
  • J. A. Wise
    • Natural Alternatives International
Article

DOI: 10.1007/s00726-006-0299-9

Cite this article as:
Harris, R., Tallon, M., Dunnett, M. et al. Amino Acids (2006) 30: 279. doi:10.1007/s00726-006-0299-9

Summary.

β-Alanine in blood-plasma when administered as A) histidine dipeptides (equivalent to 40 mg · kg−1 bwt of β-alanine) in chicken broth, or B) 10, C) 20 and D) 40 mg · kg−1 bwt β-alanine (CarnoSyn™, NAI, USA), peaked at 428 ± SE 66, 47 ± 13, 374 ± 68 and 833 ± 43 µM. Concentrations regained baseline at 2 h. Carnosine was not detected in plasma with A) although traces of this and anserine were found in urine. Loss of β-alanine in urine with B) to D) was <5%. Plasma taurine was increased by β-alanine ingestion but this did not result in any increased loss via urine. Pharmacodynamics were further investigated with 3 × B) per day given for 15 d. Dietary supplementation with I) 3.2 and II) 6.4 g · d−1 β-alanine (as multiple doses of 400 or 800 mg) or III) L-carnosine (isomolar to II) for 4 w resulted in significant increases in muscle carnosine estimated at 42.1, 64.2 and 65.8%.

Keywords: Carnosine – β-Alanine – Muscle – Buffering – Intracellular pH

Copyright information

© Springer-Verlag 2006