Amino Acids

, Volume 32, Issue 1, pp 101–108

Abnormal changes of plasma acute phase proteins in schizophrenia and the relation between schizophrenia and haptoglobin (Hp) gene

  • C. Wan
  • Y. La
  • H. Zhu
  • Y. Yang
  • L. Jiang
  • Y. Chen
  • G. Feng
  • H. Li
  • H. Sang
  • X. Hao
  • G. Zhang
  • L. He
Article

DOI: 10.1007/s00726-005-0292-8

Cite this article as:
Wan, C., La, Y., Zhu, H. et al. Amino Acids (2007) 32: 101. doi:10.1007/s00726-005-0292-8

Summary.

In this study we focused on detecting schizophrenia related changes of plasma proteins using proteomic technology and examining the relation between schizophrenia and haptoglobin (Hp) genotype. We investigated plasma proteins from schizophrenic subjects (n = 42) and healthy controls (n = 46) by two-dimensional gel electrophoresis (2-DE) in combination with mass spectrometry. To further reveal the genetic relationship between acute phase proteins (APPs) and schizophrenia disease, we tested Hp α1/Hp α2 (Hp 1/2) polymorphism and two single nucleotide polymorphisms (SNPs) of Hp, rs2070937 and rs5473, for associations with schizophrenia in the Chinese Han population. With the relatively high number of samples for 2-DE work, we found that four proteins in the family of positive APPs were all up-regulated in patients. In genetic association study, we found significant associations existing between schizophrenia and Hp polymorphisms, Hp 1/2 and rs2070937 variants. Schizophrenia is accompanied by both an altered expression of Hp protein and a different genotype distribution of Hp gene, demonstrating that Hp is associated with schizophrenia. The results from proteomic and genomic aspects both indicate that acute phase reaction is likely to be an aetiological agent in the pathophysiology of schizophrenia, but not just an accompanying symptom. The positive APPs are schizophrenic related proteins, with the highly concordant results on four positive APPs.

Keywords: Schizophrenia – Acute phase proteins – Proteomics – Plasma – Haptoglobin 

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • C. Wan
    • 1
    • 2
  • Y. La
    • 1
    • 2
  • H. Zhu
    • 1
    • 2
  • Y. Yang
    • 1
    • 2
  • L. Jiang
    • 1
    • 2
  • Y. Chen
    • 1
    • 2
  • G. Feng
    • 3
  • H. Li
    • 3
  • H. Sang
    • 4
  • X. Hao
    • 4
  • G. Zhang
    • 5
  • L. He
    • 1
    • 2
  1. 1.Bio-X Life Science Research CenterShanghai Jiao Tong UniversityShanghaiChina
  2. 2.Institutes for Nutritional Sciences, Shanghai Institute of Biological SciencesChinese Academy of SciencesShanghaiChina
  3. 3.Shanghai Institute of Mental HealthShanghaiChina
  4. 4.Kaixuan Hospital of ChangchunJilin ProvinceChina
  5. 5.Shanghai Zhabei Institute of Mental HealthShanghaiChina