Minireview Article

Amino Acids

, Volume 28, Issue 3, pp 273-278

First online:

Long-chain acyl-CoA hydrolase in the brain

  • J. YamadaAffiliated withDepartment of Clinical Biochemistry, Tokyo University of Pharmacy and Life Science

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Summary.

Long-chain acyl-CoA hydrolases are a group of enzymes that cleave acyl-CoAs into fatty acids and coenzyme A (CoA-SH). Because acyl-CoAs participate in numerous reactions encompassing lipid synthesis, energy metabolism and regulation, modulating intracellular levels of acyl-CoAs would affect cellular functions. Therefore, acyl-CoA synthetases have been intensively studied. In contrast, acyl-CoA hydrolases have been less investigated, especially in the brain despite the fact that its long-chain acyl-CoA hydrolyzing activity is much higher than that in any other organ in the body. However, recent studies have dissected the multiplicity of this class of enzymes on a genomic basis, and have allowed us to discuss their function. Here, we describe a cytosolic long-chain acyl-CoA hydrolase (referred to as BACH) that is constitutively expressed in the brain, comparing it with other acyl-CoA hydrolases found in peripheral organs that have a role in fatty acid oxidation.

Keywords: Acyl-CoA thioesterase – Long-chain fatty acyl-CoA – Lipid metabolism – Neuron