Review

Monatshefte für Chemie - Chemical Monthly

, Volume 142, Issue 4, pp 331-340

Human diseases related to aluminium overload

  • Guido CrisponiAffiliated withDipartimento di Scienze Chimiche, University of Cagliari Email author 
  • , Valeria M. NurchiAffiliated withDipartimento di Scienze Chimiche, University of Cagliari
  • , Gavino FaaAffiliated withDipartimento di Citomorfologia, Divisione di Anatomia Patologica, University of Cagliari
  • , Maurizio RemelliAffiliated withDipartimento di Chimica, University of Ferrara

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Abstract

In this paper attention is devoted to the role of aluminium in osteodistrophy and dialysis dementia. In fact, these diseases, in spite of the actions that have drastically reduced their occurrence, have so far constituted a cause of great medical concern. As a preliminary point, some aspects concerning the solution chemistry of aluminium are considered, then the medical problems are described and finally the chelation therapy of aluminium overload, giving some insight on the chelators recently proposed.

Graphical abstract

http://static-content.springer.com/image/art%3A10.1007%2Fs00706-011-0474-x/MediaObjects/706_2011_474_Figa_HTML.gif

Keywords

Aluminium overload Ligands Metal complexes Chelation therapy Bioinorganic chemistry