Monatshefte für Chemie - Chemical Monthly

, Volume 139, Issue 12, pp 1537–1544

Genomics of selected human odorant receptors

  • Kirsten Knape
  • Anton Beyer
  • Anna Stary
  • Gerhard Buchbauer
  • Peter Wolschann
Open AccessArticle

DOI: 10.1007/s00706-008-0957-6

Cite this article as:
Knape, K., Beyer, A., Stary, A. et al. Monatsh Chem (2008) 139: 1537. doi:10.1007/s00706-008-0957-6

Abstract

Single nucleotide polymorphisms (SNPs) in odorant receptor genes may influence the protein sequence and consequently also the function of the receptors. An analysis of the HapMap data for human OR3A1 was performed and provided evidence that genetic differences subject to ancestry and gender can be recognized. A genomic comparison of individuals shows the diversity of odorant receptor genes and therefore potentially the variety of the sense of smell. At this time, two complete human genomes are available in public domain, which we used for this purpose.

Keywords

Odorant receptor; OR3A1; Genomics; Single nucleotide polymorphism. 
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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Kirsten Knape
    • 1
  • Anton Beyer
    • 2
  • Anna Stary
    • 2
    • 3
  • Gerhard Buchbauer
    • 1
  • Peter Wolschann
    • 2
  1. 1.Department of Clinical Pharmacy and DiagnosticsUniversity of ViennaViennaAustria
  2. 2.Institute of Theoretical ChemistryUniversity of ViennaViennaAustria
  3. 3.Present address: Computational Biomolecular Dynamics GroupMax-Planck-Institute for Biophysical ChemistryGöttingenGermany