Archives of Virology

, Volume 145, Issue 12, pp 2601–2618

Immune responses and cytokine induction in the development of severe hepatitis during acute infections with murine cytomegalovirus

  • J. Trgovcich
  • D. Štimac
  • B. Polić
  • A. Krmpotić
  • E. Pernjak-Pugel
  • J. Tomac
  • M. Hasan
  • B. Wraber
  • S. Jonjić

DOI: 10.1007/s007050070010

Cite this article as:
Trgovcich, J., Štimac, D., Polić, B. et al. Arch. Virol. (2000) 145: 2601. doi:10.1007/s007050070010

Summary.

 Salivary gland-derived murine cytomegalovirus (SGV) infections of mice have been widely used as models of human cytomegalovirus infections and in the study of CMV biology. Still, many aspects of SGV pathogenesis are not clearly defined. Fatal and non-fatal SGV infections were investigated to characterize pathogenetic correlates of mortality and to assess the role of the immune response in disease progression. Suppression of immune responses was observed in both lethal and sublethal infections. Depletion of immune cell populations in spleen, however, correlated with severe CMV-induced hepatitis and mortality. In addition, T cell depletion studies indicated a requirement for this immune cell subset in control of liver damage and survival of infected mice. Examination of cytokine responses revealed a previously undescribed shock-like syndrome in lethally-infected mice characterized by high levels of tumor necrosis factor α and interferon γ. Furthermore, the sites of tumor necrosis factor α gene induction did not strictly correlate with either viral load or the sites of tissue damage during infection. Taken together, these findings define the pathogenetic progression of disease as it relates to disease outcome and suggests that organ-specific differences in cytokine induction play a significant role in the late stages of acute lethal MCMV infections.

Copyright information

© Springer-Verlag/Wien 2000

Authors and Affiliations

  • J. Trgovcich
    • 1
  • D. Štimac
    • 1
  • B. Polić
    • 1
  • A. Krmpotić
    • 1
  • E. Pernjak-Pugel
    • 1
  • J. Tomac
    • 1
  • M. Hasan
    • 1
  • B. Wraber
    • 2
  • S. Jonjić
    • 1
  1. 1. Department of Histology and Embryology, Medical Faculty, University of Rijeka, Rijeka, Croatia
  2. 2. Institute of Microbiology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia

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