Archives of Virology

, Volume 143, Issue 4, pp 697–715

Genetically determined resistance to flavivirus infection in wild Mus musculus domesticus and other taxonomic groups in the genus Mus

  • M. Y. Sangster
  • J. S. Mackenzie
  • G. R. Shellam
Article

DOI: 10.1007/s007050050324

Cite this article as:
Sangster, M.Y., Mackenzie, J.S. & Shellam, G.R. Arch. Virol. (1998) 143: 697. doi:10.1007/s007050050324

Summary

Inherited resistance to flaviviruses in laboratory mice is a rare trait conferred by an autosomal dominant gene (Flvr). To provide information on genetic resistance to flaviviruses in wild mice, we analysed (i) wild M. m. domesticus trapped in Australia, and (ii) mice representing other species and subspecies in the genus Mus. Mice were screened for resistance relative to C3H/HeJ mice by intracerebral challenge with Murray Valley encephalitis virus or yellow fever virus, and breeding studies were undertaken to identify inherited resistance factors. Widespread flavivirus resistance was demonstrated in Australian M. m. domesticus. A single, autosomal dominant Flvr-like gene appeared to be primarily responsible, but there was some evidence for additional inherited resistance factors. Flavivirus resistance was also identified in other taxonomic groups, and a genetic basis for this resistance was demonstrated in M. m. musculus (Skive), M. spretus, and M. spicilegus. Interestingly, M. m. musculus (CZI-O) were more susceptible than C3H/HeJ mice. Our findings show that genetic resistance to flaviviruses is common in divergent taxonomic groups in the genus Mus, suggesting that the trait has an ancient evolutionary origin, but whether flavivirus resistance genes have an anti-viral role or serve some other function is unknown.

Copyright information

© Springer-Verlag 1998

Authors and Affiliations

  • M. Y. Sangster
    • 1
  • J. S. Mackenzie
    • 1
  • G. R. Shellam
    • 1
  1. 1.Department of Microbiology, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, Western Australia, AustraliaAustralia