Archives of Virology

, Volume 159, Issue 10, pp 2745–2749

Low infectivity of a novel avian-origin H7N9 influenza virus in pigs

  • Jung Yum
  • Eun Hye Park
  • Keun Bon Ku
  • Ji An Kim
  • Seung Kyoo Oh
  • Hyun Soo Kim
  • Sang Heui Seo
Brief Report

DOI: 10.1007/s00705-014-2143-y

Cite this article as:
Yum, J., Park, E.H., Ku, K.B. et al. Arch Virol (2014) 159: 2745. doi:10.1007/s00705-014-2143-y

Abstract

We studied the pathogenesis and transmissibility of a novel avian-origin H7N9 influenza virus in pigs. When pigs were infected with H7N9 influenza virus, they did not show any clear clinical signs (such as sneezing, fever and loss of body weight), and they shed viruses through their noses for 2 days after infection. No transmission occurred between infected and naïve pigs. Pigs suffered from mild pneumonia, which was accompanied by the induction of inflammatory cytokines and chemokines such as IL-8 and CCL1. Taken together, our results suggest that pigs may not play an active role in transmitting H7N9 influenza virus to mammals.

Keywords

Influenza virus H7N9 Pathogenesis Pigs 

Copyright information

© Springer-Verlag Wien 2014

Authors and Affiliations

  • Jung Yum
    • 1
    • 2
  • Eun Hye Park
    • 1
    • 2
  • Keun Bon Ku
    • 1
    • 2
  • Ji An Kim
    • 1
    • 2
  • Seung Kyoo Oh
    • 1
    • 2
  • Hyun Soo Kim
    • 3
  • Sang Heui Seo
    • 1
    • 2
  1. 1.Laboratory of Influenza Research, College of Veterinary Medicine, Institute for Influenza VirusChungnam National UniversityDaejeonRepublic of Korea
  2. 2.Institute of Influenza Virus, College of Veterinary MedicineChungnam National UniversityDaejeonRepublic of Korea
  3. 3.Laboratory of Public Health, College of Veterinary MedicineChungnam National UniversityDaejeonRepublic of Korea