Archives of Virology

, Volume 158, Issue 11, pp 2365–2370

Oseltamivir-resistant influenza viruses isolated in South Korea from 2005 to 2010

  • Han-Gil Cho
  • Jang-Hoon Choi
  • Hyun-Kyung Lee
  • Su-Kyoung Mun
  • Jong-Bok Lee
  • Eek-Hoon Jho
  • Chun Kang
  • Young-Hee Lim
Brief Report

DOI: 10.1007/s00705-013-1734-3

Cite this article as:
Cho, H., Choi, J., Lee, H. et al. Arch Virol (2013) 158: 2365. doi:10.1007/s00705-013-1734-3

Abstract

South Korean isolates of oseltamivir-resistant influenza viruses from 2005–2010 were investigated with a total 491 influenza viruses identified from 1702 specimens. Neuraminidase genes from 342 influenza viruses (71 A/H1N1, 74 pandemic A/H1N1 2009, 117 A/H3N2, and 80 B) were analyzed by RT-PCR with molecular markers for oseltamivir resistance. The H274Y mutation in the NA protein was identified in 100 % (n=40) of A/H1N1 viruses circulating in 2008–2009. Influenza A/H1N1 viruses harboring the H274Y substitution exhibited, on average, a 626-fold reduction in oseltamivir susceptibility and clustered with the A/Norway/1736/2007 strain. Close and timely monitoring for resistance to clinically available influenza antivirals should be consistently performed.

Keywords

Influenza virusesNeuraminidaseOseltamivir resistance

Supplementary material

705_2013_1734_MOESM1_ESM.doc (174 kb)
Supplementary material 1 (DOC 173 kb)

Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  • Han-Gil Cho
    • 2
    • 4
  • Jang-Hoon Choi
    • 3
  • Hyun-Kyung Lee
    • 2
  • Su-Kyoung Mun
    • 2
  • Jong-Bok Lee
    • 2
  • Eek-Hoon Jho
    • 4
  • Chun Kang
    • 3
  • Young-Hee Lim
    • 1
  1. 1.Department of Biomedical Science, College of Health ScienceKorea UniversitySeoulSouth Korea
  2. 2.Gyeonggi-do Institute of Health and EnvironmentSuwonSouth Korea
  3. 3.Center for Infectious DiseasesNational Institute of Health, Korea Centers for Disease Control and PreventionCheongwon-gunSouth Korea
  4. 4.University of SeoulSeoulSouth Korea