Archives of Virology

, Volume 157, Issue 8, pp 1579–1586

Correlation of viral load with bone marrow and hematological changes in pale patients with chronic hepatitis C virus

Authors

  • Abdel Raouf Abou El Azm
    • Department of Tropical Medicine and Infectious DiseasesTanta University
  • Hassan El-Bate
    • Department of Tropical Medicine and Infectious DiseasesTanta University
  • Lobna Abo-Ali
    • Department of Tropical Medicine and Infectious DiseasesTanta University
  • Nagwa Mansour
    • Department of Clinical PathologyTanta University
  • Hussin Ghoraba
    • Department of PathologyTanta University
    • Department of Zoology, Faculty of Science, Immunology and Biotechnology UnitTanta University
Brief Report

DOI: 10.1007/s00705-012-1321-z

Cite this article as:
Abou El Azm, A.R., El-Bate, H., Abo-Ali, L. et al. Arch Virol (2012) 157: 1579. doi:10.1007/s00705-012-1321-z

Abstract

Liver is considered the target of hepatitis C virus (HCV), which has marked tropism for hepatocytes. In this study, we investigated changes in bone marrow (BM) and blood and their correlation with viremia level in 30 pale patients with chronic HCV who were selected before antiviral therapy. Patients with BM positive for HCV RNA (53.33 %) showed moderate to high viremia, while patients with BM negative for RNA (46.67 %) had low viremia. There was no significant difference in the liver histopathology between patients with HCV-RNA-negative and positive BM. Patients with BM positive for HCV RNA showed significant changes in BM cells, including the degree of immune complex deposition and alterations in peripheral blood counts compared to patients with BM negative for RNA and healthy controls, suggesting that BM changes could be a sequel or a reservoir for HCV viremia.

Copyright information

© Springer-Verlag 2012