Archives of Virology

, Volume 156, Issue 8, pp 1397–1413

Uniformity of rotavirus strain nomenclature proposed by the Rotavirus Classification Working Group (RCWG)

Authors

    • Laboratory of Clinical & Epidemiological Virology, Department of Microbiology & Immunology, Rega Institute for Medical ResearchUniversity of Leuven
  • Max Ciarlet
    • Clinical Research and DevelopmentNovartis Vaccines & Diagnostics, Inc
  • Sarah M. McDonald
    • Laboratory of Infectious Diseases, National Institute of Allergy and Infectious DiseasesNational Institutes of Health
  • Houssam Attoui
    • Vector-Borne Diseases ProgramInstitute for Animal Health
  • Krisztián Bányai
    • Veterinary Medical Research InstituteHungarian Academy of Sciences
  • J. Rodney Brister
    • National Center for Biotechnology Information, National Library of MedicineNational Institutes of Health
  • Javier Buesa
    • Department of Microbiology and Ecology, School of MedicineUniversity of Valencia
  • Mathew D. Esona
    • Division of Viral Diseases, National Center for Immunization and Respiratory DiseasesCenters for Disease Control and Prevention
  • Mary K. Estes
    • Department of Molecular Virology and Microbiology and Medicine-GIBaylor College of Medicine
  • Jon R. Gentsch
    • Division of Viral Diseases, National Center for Immunization and Respiratory DiseasesCenters for Disease Control and Prevention
  • Miren Iturriza-Gómara
    • Enteric Virus Unit, Virus Reference Department, Centre for InfectionHealth Protection Agency
  • Reimar Johne
    • Federal Institute for Risk Assessment
  • Carl D. Kirkwood
    • Enteric Virus Research Group, Murdoch Childrens Research InstituteRoyal Children’s Hospital
  • Vito Martella
    • Department of Veterinary Public HealthUniversity of Bari
  • Peter P. C. Mertens
    • Vector-Borne Diseases ProgramInstitute for Animal Health
  • Osamu Nakagomi
    • Department of Molecular Microbiology and ImmunologyNagasaki University
  • Viviana Parreño
    • Instituto de VirologíaCICVyA, INTA Castelar
  • Mustafizur Rahman
    • Laboratory of VirologyICDDR,B
  • Franco M. Ruggeri
    • Department of Veterinary Public Health & Food SafetyIstituto Superiore di Sanità
  • Linda J. Saif
    • Food Animal Health Research Program, Ohio Agricultural Research and Development CenterThe Ohio State University
  • Norma Santos
    • Departamento de Virologia, Instituto de MicrobiologiaUniversidade Federal do Rio de Janeiro
  • Andrej Steyer
    • University of Ljubljana, Faculty of Medicine, Institute of Microbiology and Immunology
  • Koki Taniguchi
    • Department of Virology and ParasitologyFujita Health University School of Medicine
  • John T. Patton
    • Laboratory of Infectious Diseases, National Institute of Allergy and Infectious DiseasesNational Institutes of Health
  • Ulrich Desselberger
    • Department of Medicine, Addenbrooke’s HospitalUniversity of Cambridge
  • Marc Van Ranst
    • Laboratory of Clinical & Epidemiological Virology, Department of Microbiology & Immunology, Rega Institute for Medical ResearchUniversity of Leuven
Original Article

DOI: 10.1007/s00705-011-1006-z

Cite this article as:
Matthijnssens, J., Ciarlet, M., McDonald, S.M. et al. Arch Virol (2011) 156: 1397. doi:10.1007/s00705-011-1006-z

Abstract

In April 2008, a nucleotide-sequence-based, complete genome classification system was developed for group A rotaviruses (RVs). This system assigns a specific genotype to each of the 11 genome segments of a particular RV strain according to established nucleotide percent cutoff values. Using this approach, the genome of individual RV strains are given the complete descriptor of Gx-P[x]-Ix-Rx-Cx-Mx-Ax-Nx-Tx-Ex-Hx. The Rotavirus Classification Working Group (RCWG) was formed by scientists in the field to maintain, evaluate and develop the RV genotype classification system, in particular to aid in the designation of new genotypes. Since its conception, the group has ratified 51 new genotypes: as of April 2011, new genotypes for VP7 (G20-G27), VP4 (P[28]-P[35]), VP6 (I12-I16), VP1 (R5-R9), VP2 (C6-C9), VP3 (M7-M8), NSP1 (A15-A16), NSP2 (N6-N9), NSP3 (T8-T12), NSP4 (E12-E14) and NSP5/6 (H7-H11) have been defined for RV strains recovered from humans, cows, pigs, horses, mice, South American camelids (guanaco), chickens, turkeys, pheasants, bats and a sugar glider. With increasing numbers of complete RV genome sequences becoming available, a standardized RV strain nomenclature system is needed, and the RCWG proposes that individual RV strains are named as follows: RV group/species of origin/country of identification/common name/year of identification/G- and P-type. In collaboration with the National Center for Biotechnology Information (NCBI), the RCWG is also working on developing a RV-specific resource for the deposition of nucleotide sequences. This resource will provide useful information regarding RV strains, including, but not limited to, the individual gene genotypes and epidemiological and clinical information. Together, the proposed nomenclature system and the NCBI RV resource will offer highly useful tools for investigators to search for, retrieve, and analyze the ever-growing volume of RV genomic data.

Copyright information

© Springer-Verlag 2011