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Molecular characterization of rare G12P[6] rotavirus isolates closely related to G12 strains from the United States, CAU 195 and CAU 214

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Abstract

Two human G12 rotaviruses, CAU 195 and CAU 214, were isolated from South Korea using cell culture and characterized on the basis of sequence divergence in the VP7, VP4, and NSP4 genes. Phylogenetic analysis of the VP7 gene sequences indicated that these strains clustered into lineage III and were most closely related to G12 rotaviruses isolated in the United States. The VP4 and NSP4 gene sequences showed that two strains belonged to the P[6]-Ia lineage and genotype [B]. This finding provides information that can be used to evaluate G12 strains and aid in the development of effective vaccines in the future.

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Acknowledgments

This study was supported by a grant from the BioGreen 21 Program (Code 200901FHT020814288), funded by the Rural Development Administration, Republic of Korea.

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Authors and Affiliations

  1. Department of Microbiology, College of Medicine, Chung-Ang University, Seoul, South Korea

    Van Phan Le, Yoosik Yoon, Kijeong Kim, Sang-In Chung & Wonyong Kim

  2. Functional Biomaterial Division, National Academy of Agricultural Science, RDA, Suwon, South Korea

    Jong Bum Kim

  3. Food Immunology Research Group, Korea Food Research Institute, Seongnam, South Korea

    Dong Hwa Shon

  4. Department of Genetic Engineering and Graduate School of Biotechnology, Kyung Hee University, Suwon, South Korea

    In Sik Chung

  5. Department of Pediatrics, College of Medicine, Chung-Ang University, Seoul, Korea

    Inseok Lim

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  1. Van Phan Le
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Correspondence to Wonyong Kim.

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Le, V.P., Kim, J.B., Shon, D.H. et al. Molecular characterization of rare G12P[6] rotavirus isolates closely related to G12 strains from the United States, CAU 195 and CAU 214. Arch Virol 156, 511–516 (2011). https://doi.org/10.1007/s00705-010-0865-z

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  • DOI: https://doi.org/10.1007/s00705-010-0865-z

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