, Volume 154, Issue 11, pp 1823-1829
Date: 18 Sep 2009

Molecular characterization of a rare, human-porcine reassortant rotavirus strain, G11P[6], from Ecuador

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


The Pan-American Health Organization established a rotavirus pre-vaccination disease burden and strain surveillance network in Latin America and the Caribbean in 2004. During strain surveillance in Ecuador in 2005–2006, a rare rotavirus genotype, G11P[6], was detected among common strains. Sequencing and phylogenetic analysis of this strain identified a novel lineage of the G11 VP7 gene, most closely related to A253 (91.8% nt identity), a porcine rotavirus strain identified in Venezuela. Most genes of this strain clustered with porcine, human-porcine or bovine-porcine reassortant strains; only VP6 and perhaps NSP2 genes were more closely related to cognate genes of human rotaviruses. Thus, this strain was likely generated by gene reassortment between porcine and human parental strains. Our study provides further evidence that animal rotaviruses play an important role in genetic and antigenic diversity of rotaviruses pathogenic for humans.

K. Bányai and M. D. Esona have equally contributed to this work.
An erratum to this article can be found at http://dx.doi.org/10.1007/s00705-009-0531-5