Archives of Virology

, Volume 154, Issue 4, pp 699–707

Evidence of diversification of dengue virus type 3 genotype III in the South American region

  • Domenica de Mora
  • Lucía D’ Andrea
  • Macarena Alvarez
  • Mary Regato
  • Alvaro Fajardo
  • Ricardo Recarey
  • Rodney Colina
  • Baldip Khan
  • Juan Cristina
Brief Report

DOI: 10.1007/s00705-009-0343-7

Cite this article as:
de Mora, D., Andrea, L.D., Alvarez, M. et al. Arch Virol (2009) 154: 699. doi:10.1007/s00705-009-0343-7

Abstract

In order to gain insight into the genetic variability of dengue virus type 3 (DENV-3) genotype III isolated in the Latin American region, phylogenetic analysis were carried out using envelope (E) gene sequences from 57 DENV-3 genotype III strains isolated in 11 Latin American countries. At least six different genotype III clades were observed. Amino acids substitutions were found in domain III E protein neutralization epitopes and in surface-exposed domain II and III E protein amino acid sequences.

Supplementary material

705_2009_343_MOESM1_ESM.pdf (30 kb)
Supplementary material 1 (PDF 30 kb)
705_2009_343_MOESM2_ESM.doc (218 kb)
Supplementary material 2 (DOC 218 kb)
705_2009_343_MOESM3_ESM.doc (52 kb)
Supplementary material 3 (DOC 52 kb)
705_2009_343_MOESM4_ESM.doc (35 kb)
Supplementary material 4 (DOC 35 kb)

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Domenica de Mora
    • 1
  • Lucía D’ Andrea
    • 2
  • Macarena Alvarez
    • 2
  • Mary Regato
    • 1
  • Alvaro Fajardo
    • 2
  • Ricardo Recarey
    • 2
  • Rodney Colina
    • 2
  • Baldip Khan
    • 3
  • Juan Cristina
    • 2
  1. 1.Instituto Nacional de Higiene y Medicina Tropical “Leopoldo Inquieta Perez”GuayaquilEcuador
  2. 2.Laboratorio de Virología MolecularFacultad de Ciencias, Centro de Investigaciones NuclearesMontevideoUruguay
  3. 3.Division of Human HealthInternational Atomic Energy AgencyViennaAustria

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