Evidence of diversification of dengue virus type 3 genotype III in the South American region
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- de Mora, D., Andrea, L.D., Alvarez, M. et al. Arch Virol (2009) 154: 699. doi:10.1007/s00705-009-0343-7
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In order to gain insight into the genetic variability of dengue virus type 3 (DENV-3) genotype III isolated in the Latin American region, phylogenetic analysis were carried out using envelope (E) gene sequences from 57 DENV-3 genotype III strains isolated in 11 Latin American countries. At least six different genotype III clades were observed. Amino acids substitutions were found in domain III E protein neutralization epitopes and in surface-exposed domain II and III E protein amino acid sequences.