, Volume 154, Issue 4, pp 699-707
Date: 26 Mar 2009

Evidence of diversification of dengue virus type 3 genotype III in the South American region

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In order to gain insight into the genetic variability of dengue virus type 3 (DENV-3) genotype III isolated in the Latin American region, phylogenetic analysis were carried out using envelope (E) gene sequences from 57 DENV-3 genotype III strains isolated in 11 Latin American countries. At least six different genotype III clades were observed. Amino acids substitutions were found in domain III E protein neutralization epitopes and in surface-exposed domain II and III E protein amino acid sequences.

Nucleotide sequence data reported are available in the EMBL database under accessions numbers FM246466 through FM246471 and FM246473.