Archives of Virology

, 153:1281

Genomic analysis of Newcastle disease virus strain NA-1 isolated from geese in China

  • M. Xu
  • S. Chang
  • Z. Ding
  • H.-W. Gao
  • J.-Y. Wan
  • W.-S. Liu
  • L.-N. Liu
  • Y. Gao
  • J. Xu
Original Article

DOI: 10.1007/s00705-008-0115-9

Cite this article as:
Xu, M., Chang, S., Ding, Z. et al. Arch Virol (2008) 153: 1281. doi:10.1007/s00705-008-0115-9

Abstract

Newcastle disease virus (NDV) has been thought to infect only domestic avian species, with waterfowl such as geese either not being infected, even by virulent strains, or developing only in apparent infection. In 1997, a new infectious disease producing high morbidity and mortality among geese broke out in many provinces of China, which was caused by a serotype I avian paramyxovirus (APMV-1)—NDV. To investigate how NDV spreads between chickens and geese, the complete genome of one NDV strain isolated from a goose was cloned and analyzed. The results indicate that there is conservation in NDV structural genetic evolution but that there are also considerable differences between goose and chicken NDV strains. Separate patterns of NDV evolution exist among wild bird species. Meanwhile, there is evidence indicating that the goose NDV may have evolved from chicken NDV strain Herts/33. In addition, the possibility was investigated that this new strain of NDV may bind to different sialic acid receptor binding sites than the normal NDV strains that have been investigated so far. This might provide clues to the evolution of the goose NDV.

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • M. Xu
    • 1
    • 2
  • S. Chang
    • 1
  • Z. Ding
    • 1
  • H.-W. Gao
    • 2
  • J.-Y. Wan
    • 2
  • W.-S. Liu
    • 2
  • L.-N. Liu
    • 2
  • Y. Gao
    • 1
    • 2
  • J. Xu
    • 2
  1. 1.Laboratory of Important Pathogen and Loemia of Animal, College of Animal and Veterinary ScienceJilin UniversityChangchunPeople’s Republic of China
  2. 2.Military Institute of Veterinary SciencesAcademy of Military Medical SciencesChangchunPeople’s Republic of China

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