Archives of Virology

, Volume 153, Issue 5, pp 831–837

Chitosan as an adjuvant for parenterally administered inactivated influenza vaccines

Original Article

DOI: 10.1007/s00705-008-0047-4

Cite this article as:
Ghendon, Y., Markushin, S., Krivtsov, G. et al. Arch Virol (2008) 153: 831. doi:10.1007/s00705-008-0047-4


The addition of 0.5% of a chitosan derivative to inactivated influenza vaccines injected parenterally resulted in a four or six to tenfold increase in antibody titres after a single-dose or two-dose intramuscular immunization of mice, respectively, in comparison with antibody titres after immunization without chitosan. Chitosan-adjuvanted vaccines enhanced antibody titers against drift variants of A- and B-type human influenza viruses four to six times compared with the vaccines without chitosan. Inactivated avian influenza virus A/H5N2 admixed with chitosan, when administered to mice challenged afterwards with the same virus, showed higher immunogenicity and protective efficacy compared with the antigen without chitosan.

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Y. Ghendon
    • 1
  • S. Markushin
    • 1
  • G. Krivtsov
    • 1
  • I. Akopova
    • 1
  1. 1.Mechnikov Research Institute for Vaccines and SeraMoscowRussia

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