Archives of Virology

, Volume 153, Issue 4, pp 667–674

Genetic variations in the gB, UL144 and UL149 genes of human cytomegalovirus strains collected from congenitally and postnatally infected Japanese children

Authors

  • Hainian Yan
    • Department of Virology INational Institute of Infectious Diseases
    • Department of Developmental Medical Sciences, Institute of International Health, Graduate School of MedicineThe University of Tokyo
  • Shin Koyano
    • Department of PediatricsAsahikawa Medical College
  • Yuhki Inami
    • Department of Virology INational Institute of Infectious Diseases
  • Yumiko Yamamoto
    • Department of Virology INational Institute of Infectious Diseases
  • Tatsuo Suzutani
    • Department of MicrobiologyFukushima Medical University
  • Masashi Mizuguchi
    • Department of Developmental Medical Sciences, Institute of International Health, Graduate School of MedicineThe University of Tokyo
  • Hiroshi Ushijima
    • Department of Developmental Medical Sciences, Institute of International Health, Graduate School of MedicineThe University of Tokyo
  • Ichiro Kurane
    • Department of Virology INational Institute of Infectious Diseases
    • Department of Virology INational Institute of Infectious Diseases
Original Article

DOI: 10.1007/s00705-008-0044-7

Cite this article as:
Yan, H., Koyano, S., Inami, Y. et al. Arch Virol (2008) 153: 667. doi:10.1007/s00705-008-0044-7

Abstract

Human cytomegalovirus (CMV) is the leading cause of intrauterine viral infection. The association of genetic polymorphisms in some particular genes with the incidence and severity of congenital infection has been controversial. To address this issue, we analyzed the genotypes of the glycoprotein B (gB), UL144 and UL149 genes of CMV clinical strains obtained from 33 congenitally and 31 postnatally infected Japanese children. Our results demonstrated that (1) CMV strains with any combination of genotypes could be vertically transmitted from mother to fetus, potentially causing neurological abnormalities, (2) the gB3 genotype was more prevalent in the congenital cases than in postnatally infected children (P < 0.05), particularly in congenital cases with sensorineural hearing loss (P = 0.009), (3) there was no relationship between gB genotype and viral load in the urine and dried umbilical cord specimens in the congenital cases, and (4) the UL144 and UL149 genotype distributions had no bias for congenial infection. In future studies, it would be interesting to see whether the gB genotypes serve as a prognostic indicator of CMV-associated diseases.

Abbreviations

CMV

Cytomegalovirus

PCR

Polymerase chain reaction

SNHL

Sensorineural hearing loss

Copyright information

© Springer-Verlag 2008