, Volume 153, Issue 1, pp 211-217
Date: 15 Nov 2007

Genetic analysis of four porcine avian influenza viruses isolated from Shandong, China

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A Bayesian phylogenetic analysis of eight separate gene segments indicated A/Swine/Shandong/2/2003 (H5N1), A/Swine/Shandong/na/2003 (H9N2), A/Swine/Shandong/nb/2003 (H9N2) and A/Swine/Shandong/nc/2005 (H9N2) probably represent two multiple reassortant lineages, that had not been described before, with genes coming from H5N1, H9N2 and other lineages from poultry in Asia. Amino acid motifs within the haemagglutinin sequence of A/Swine/Shandong/nb/2003 suggested it may be able to infect people, whereas the sequences of the other three isolates suggested they would not have had that capability. Our analysis emphasizes the need for a comprehensive study of the interactions between H5N1 and H9N2 viruses in Asia that includes sequencing and phylogenetic investigation.

Correspondence: Wei Feng Shi, Institute of Life Sciences, Taishan Medical College, Shandong Tai’an 271000, China.
Dr. Chao Dong Zhu, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.