Archives of Virology

, Volume 151, Issue 10, pp 2047–2053

The activation of lytic replication of Epstein-Barr virus by baculovirus-mediated gene transduction

Authors

  • L. Wang
    • Department of Microbiology and Microbial Engineering, School of Life SciencesFudan University
  • L. Shan
    • Department of Microbiology and Microbial Engineering, School of Life SciencesFudan University
  • J. Yin
    • Department of Microbiology and Microbial Engineering, School of Life SciencesFudan University
  • M. Zhao
    • Department of Microbiology and Microbial Engineering, School of Life SciencesFudan University
  • D. Su
    • Department of Microbiology and Microbial Engineering, School of Life SciencesFudan University
  • J. Zhong
    • Department of Microbiology and Microbial Engineering, School of Life SciencesFudan University
Brief Report

DOI: 10.1007/s00705-006-0772-5

Cite this article as:
Wang, L., Shan, L., Yin, J. et al. Arch Virol (2006) 151: 2047. doi:10.1007/s00705-006-0772-5

Summary.

A baculoviral mammalian-cell vector was constructed to express Rta, a protein of Epstein-Barr virus (EBV) responsible for the transition from latent infection to lytic replication. EBV lytic replication and cell-growth inhibition was observed in infected D98/HR1 cells. The baculovirus caused little cytotoxicity in the non-targeted HeLa cells, compared to an adenovirus vector. It is concluded that recombinant baculovirus might have the potential as a vector for the therapy of EBV-related cancer.

Copyright information

© Springer-Verlag 2006