Archives of Virology

, Volume 151, Issue 11, pp 2243–2251

Molecular epidemiology of rabies from Maranhão and surrounding states in the northeastern region of Brazil

  • G. Sato
  • Y. Kobayashi
  • Y. Shoji
  • T. Sato
  • T. Itou
  • F. H. Ito
  • H. P. Santos
  • C. J. C. Brito
  • T. Sakai
Article

DOI: 10.1007/s00705-006-0770-7

Cite this article as:
Sato, G., Kobayashi, Y., Shoji, Y. et al. Arch Virol (2006) 151: 2243. doi:10.1007/s00705-006-0770-7
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Summary.

Although many outbreaks of rabies have been reported in northern Brazil, few epidemiological studies of these outbreaks have been undertaken. In this study, molecular epidemiological analyses were performed using 41 rabies virus samples isolated in the Maranhão (MA), Pará (PA), and Tocantins (TO) states of northeastern Brazil. A 599-bp region of the glycoprotein (G) gene was first amplified from each sample by RT-PCR, then sequenced and subjected to phylogenetic analysis. A phylogenetic tree divided the 41 isolates into two clades: Clade I was associated with terrestrial carnivores and Clade II was associated with vampire bats. The Clade I isolates were further sub-divided into two groups. The first group was closer to carnivore isolates that predominate in central Brazil, whereas the second group more closely resembled wild fox isolates from the northeastern coastal state of Paraíba (PB). MA isolates of Clade II formed an entirely separate group. These results demonstrate that bat- and dog-transmitted rabies occur in northwestern Brazil.

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • G. Sato
    • 1
  • Y. Kobayashi
    • 1
  • Y. Shoji
    • 1
  • T. Sato
    • 1
  • T. Itou
    • 1
  • F. H. Ito
    • 2
  • H. P. Santos
    • 3
  • C. J. C. Brito
    • 2
  • T. Sakai
    • 1
  1. 1.Nihon University Veterinary Research CenterNihon UniversityFujisawa, KanagawaJapan
  2. 2.Department of Preventive Veterinary Medicine and Animal Health, Faculty of the Veterinary Medicine and ZootechnyUniversity of São PauloSão PauloBrazil
  3. 3.School of Veterinary MedicineMaranhão State University, São LuísMaranhãoBrazil