Nosocomial transmission of hepatitis C virus from an anesthesiologist to three patients – epidemiologic and molecular evidence Authors
First Online: 09 December 2005 Received: 05 April 2005 Accepted: 29 September 2005 DOI:
Cite this article as: Stark, K., Hänel, M., Berg, T. et al. Arch Virol (2006) 151: 1025. doi:10.1007/s00705-005-0674-y Summary.
Acute hepatitis C occurred in three patients who had undergone gynecologic surgery in an outpatient clinic on a single day. Epidemiologic and virologic investigations revealed virus transmission from an anesthesiologist with chronic hepatitis C. HCV sequencing demonstrated that all four persons were infected by the same strain. The precise mode of transmission could not be elucidated but hygienic standards had been severely neglected.
References Altschul, SF, Gish, W, Miller, W, Myers, EW, Lipman, DJ 1990 Basic local alignment search tool J Mol Biol 215 403 410 CrossRef PubMed Centers for Disease Control 1998 Recommendations for prevention and control of hepatitis C virus (HCV) infection and HCV-related chronic disease Morb Mortal Wkly Rep 47 1 39 Cody, SH, Nainan, OV, Garfein, RS, Meyers, H, Bell, BP, Shapiro, CN, Meeks, EL, Pitt, H, Mouzin, E, Alter, MJ, Margolis, HS, Vugia, DJ 2002 Hepatitis C virus transmission from an anesthesiologist to a patient Arch Intern Med 162 345 350 CrossRef PubMed Desmet, V, Gerber, M, Hoofnagle, JH, Manns, M, Scheuer, PJ 1994 Classification of chronic hepatitis: Diagnosis, grading and staging Hepatology 19 1513 1520 CrossRef PubMed Esteban, JI, Gomez, J, Martell, M, Cabot, B, Quer, J, Camps, J, Gonzalez, A, Otero, T, Moya, A, Esteban, R, Guardia, J 1996 Transmission of hepatitis C virus by a cardiac surgeon N Engl J Med 334 555 560 CrossRef PubMed Gunson, RN Shouval, D Roggendorf, M Zaaijer, H Nicholas, H Holzmann, H de Schryver, A Reynders, D Connell, J Gerlich, WH Marinho, RT Tsantoulas, D Rigopoulou, E Rosenheim, M Valla, D Puro, V Struwe, J Tedder, R Aitken, C Alter, M Schalm, SW Carman, WF European Consensus Group 2003 Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in health care workers: guidelines for prevention of transmission of HBV and HCV from HCW to patient J Clin Virol 27 213 230 CrossRef PubMed Mawdsley, J, Teo, CG, Kyi, M, Anderson, M 2005 Anesthesist to patient transmission of hepatitis C virus associated with non exposure-prone procedures J Med Virol 75 399 401 CrossRef PubMed Poynard, T, Yuen, MF, Ratziu, V, Lai, CL 2003 Viral hepatitis C Lancet 362 2095 2100 CrossRef PubMed Ross, RS, Viazov, S, Gross, T, Hofmann, F, Seipp, HM, Roggendorf, M 2000 Transmission of hepatitis C virus from a patient to an anesthesiology assistant to five patients N Engl J Med 343 1851 1854 PubMed CrossRef Ross, RS, Viazov, S, Renzing-Kohler, K, Roggendorf, M 2000 Changes in the epidemiology of hepatitis C infection in Germany: shift in the predominance of hepatitis C subtypes J Med Virol 60 122 125 CrossRef PubMed Ross, RS, Viazov, S, Thormählen, M, Bartz, L, Tamm, J, Rautenberg, P, Roggendorf, M, Deister, A 2002 Risk of hepatitis C virus transmission from an infected gynecologist to patients: results of a 7-year retrospective investigation Arch Intern Med 162 805 810 CrossRef PubMed Sanchez-Tapias, JM 1999 Nosocomial transmission of hepatitis C virus J Hepatol 31 107 112 PubMed