Archives of Virology

, Volume 150, Issue 9, pp 1903–1909

Proposal for genetic characterisation of wild-type mumps strains: Preliminary standardisation of the nomenclature

  • L. Jin
  • B. Rima
  • D. Brown
  • C. Örvell
  • T. Tecle
  • M. Afzal
  • K. Uchida
  • T. Nakayama
  • J.-W. Song
  • C. Kang
  • P. A. Rota
  • W. Xu
  • D. Featherstone
Brief Report

DOI: 10.1007/s00705-005-0563-4

Cite this article as:
Jin, L., Rima, B., Brown, D. et al. Arch Virol (2005) 150: 1903. doi:10.1007/s00705-005-0563-4

Summary.

Though mumps virus (MuV) is a monotypic virus, genetic variation between strains has been described. Viruses have been placed into genotypes designated A–L based on the nucleotide sequence of the small hydrophobic (SH) gene, which is the most variable gene in the mumps genome. Molecular characterisation of MuV is an important component of mumps surveillance because it can help identify the transmission pathways of the virus as well as distinguish between wild-type and vaccine strains. Here, we propose a standardized nomenclature and an analysis protocol for the genetic characterisation of mumps strains to facilitate expansion of molecular epidemiological studies. In addition to assigning standard reference strains for the recognized genotypes of MuV, a convention is proposed for naming for strains and criteria to designate a new genotype.

Copyright information

© Springer-Verlag/Wien 2005

Authors and Affiliations

  • L. Jin
    • 1
  • B. Rima
    • 2
  • D. Brown
    • 1
  • C. Örvell
    • 3
  • T. Tecle
    • 3
  • M. Afzal
    • 4
  • K. Uchida
    • 5
  • T. Nakayama
    • 6
  • J.-W. Song
    • 7
  • C. Kang
    • 8
  • P. A. Rota
    • 9
  • W. Xu
    • 10
  • D. Featherstone
    • 11
  1. 1.Virus Reference DepartmentCentre for Infections, Health Protection AgencyLondonU.K.
  2. 2.Medical Biology Centre, The Queen’s University of BelfastBelfastU.K.
  3. 3.Division of Clinical VirologyHuddinge University HospitalStockholmSweden
  4. 4.Division of VirologyNational Institute for Biological Standards and ControlPotters BarU.K.
  5. 5.Virus DivisionSaitama Institute of Public HealthSaitamaJapan
  6. 6.Laboratory of Viral Infection, Kitasato Institute for Life SciencesTokyoJapan
  7. 7.Department of MicrobiologyInstitute for Viral Diseases, College of Medicine, Korea UniversitySeoulSouth Korea
  8. 8.Laboratory of Respiratory Viruses, National Institute of HealthSeoulSouth Korea
  9. 9.Measles Section, Centers for Disease Control and PreventionAtlantaU.S.A.
  10. 10.National Laboratory for Measles, Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and PreventionBeijingChina
  11. 11.Department of ImmunisationVaccines and Biologicals, World Health OrganizationGenevaSwitzerland