Brief Report

Archives of Virology

, Volume 149, Issue 11, pp 2261-2269

First online:

A novel antigenic variant of Canine parvovirus from a Vietnamese dog

  • M. NakamuraAffiliated withDepartment of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • , Y. TohyaAffiliated withDepartment of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • , T. MiyazawaAffiliated withDepartment of Veterinary Public Health, Obihiro University of Agriculture and Veterinary MedicineHost and Defense, PRESTO, Japan Science and Technology Agency
  • , M. MochizukiAffiliated withLaboratory of Clinical Microbiology, Kyoritsu Seiyaku Corporation
  • , H. T. T. PhungAffiliated withDepartment of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • , N. H. NguyenAffiliated withDepartment of Veterinary Microbiology, Infectious Diseases and Pathology, Faculty of Veterinary and Animal Science, Hanoi Agricultural University
  • , L. M. T. HuynhAffiliated withDepartment of Veterinary Microbiology, Infectious Diseases and Pathology, Faculty of Veterinary and Animal Science, Hanoi Agricultural University
  • , L. T. NguyenAffiliated withDepartment of Veterinary Microbiology, Infectious Diseases and Pathology, Faculty of Veterinary and Animal Science, Hanoi Agricultural University
  • , P. N. NguyenAffiliated withDepartment of Parasitology, Microbiology and Pathology, Faculty of Animal Science and Veterinary Medicine, University of Agriculture and Forestry
    • , P. V. NguyenAffiliated withDepartment of Parasitology, Microbiology and Pathology, Faculty of Animal Science and Veterinary Medicine, University of Agriculture and Forestry
    • , N. P. T. NguyenAffiliated withDepartment of Parasitology, Microbiology and Pathology, Faculty of Animal Science and Veterinary Medicine, University of Agriculture and Forestry
    • , H. AkashiAffiliated withDepartment of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo

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Summary.

Nine isolates of Canine parvovirus (CPV) were obtained from Vietnamese dogs and cats. One canine isolate showed a unique antigenic property which indicates a novel antigenic variant of CPV-2b when examined with hemagglutination inhibition tests using our monoclonal antibodies, 21C3 and 19D7, which were recently developed. This isolate had an amino acid substitution of residue 426, Asp to Glu, and the same substitution has recently been found in CPV from Italian dogs. This study first showed that such substitution caused an antigenic difference demonstrable by monoclonal antibodies and that a similar evolution may have occurred in CPV in Vietnam.