Archives of Virology

, Volume 149, Issue 11, pp 2261–2269

A novel antigenic variant of Canine parvovirus from a Vietnamese dog

  • M. Nakamura
  • Y. Tohya
  • T. Miyazawa
  • M. Mochizuki
  • H. T. T. Phung
  • N. H. Nguyen
  • L. M. T. Huynh
  • L. T. Nguyen
  • P. N. Nguyen
  • P. V. Nguyen
  • N. P. T. Nguyen
  • H. Akashi
Brief Report

DOI: 10.1007/s00705-004-0367-y

Cite this article as:
Nakamura, M., Tohya, Y., Miyazawa, T. et al. Arch Virol (2004) 149: 2261. doi:10.1007/s00705-004-0367-y
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Summary.

Nine isolates of Canine parvovirus (CPV) were obtained from Vietnamese dogs and cats. One canine isolate showed a unique antigenic property which indicates a novel antigenic variant of CPV-2b when examined with hemagglutination inhibition tests using our monoclonal antibodies, 21C3 and 19D7, which were recently developed. This isolate had an amino acid substitution of residue 426, Asp to Glu, and the same substitution has recently been found in CPV from Italian dogs. This study first showed that such substitution caused an antigenic difference demonstrable by monoclonal antibodies and that a similar evolution may have occurred in CPV in Vietnam.

Copyright information

© Springer-Verlag/Wien 2004

Authors and Affiliations

  • M. Nakamura
    • 1
  • Y. Tohya
    • 1
  • T. Miyazawa
    • 2
    • 3
  • M. Mochizuki
    • 4
  • H. T. T. Phung
    • 1
  • N. H. Nguyen
    • 5
  • L. M. T. Huynh
    • 5
  • L. T. Nguyen
    • 5
  • P. N. Nguyen
    • 6
  • P. V. Nguyen
    • 6
  • N. P. T. Nguyen
    • 6
  • H. Akashi
    • 1
  1. 1.Department of Veterinary MicrobiologyGraduate School of Agricultural and Life Sciences, The University of TokyoTokyoJapan
  2. 2.Department of Veterinary Public HealthObihiro University of Agriculture and Veterinary MedicineObihiroJapan
  3. 3.Host and Defense, PRESTO, Japan Science and Technology AgencyKawaguchiJapan
  4. 4.Laboratory of Clinical Microbiology, Kyoritsu Seiyaku CorporationTokyoJapan
  5. 5.Department of Veterinary Microbiology, Infectious Diseases and Pathology, Faculty of Veterinary and Animal ScienceHanoi Agricultural UniversityHanoiVietnam
  6. 6.Department of Parasitology, Microbiology and Pathology, Faculty of Animal Science and Veterinary MedicineUniversity of Agriculture and ForestryHo Chi Minh CityVietnam