Journal of Neural Transmission

, Volume 109, Issue 2, pp 191–196

Substantia nigra echogenicity is normal in non-extrapyramidal cerebral disorders but increased in Parkinson's disease

  • U. Walter
  • M. Wittstock
  • R. Benecke
  • D. Dressler
Short Communication

DOI: 10.1007/s007020200015

Cite this article as:
Walter, U., Wittstock, M., Benecke, R. et al. J Neural Transm (2002) 109: 191. doi:10.1007/s007020200015

Summary.

Transcranial sonography (TCS) revealed substantia nigra (SN) hyperechogenicity in idiopathic Parkinson's disease (IPD). To further evaluate specificity of this finding, we examined 30 IPD patients and 30 age-matched subjects with non-extrapyramidal cerebral disorders (NED). All IPD patients showed a SN hyperechogenicity, in 17 it was bilateral and in 13 unilateral. 7 NED patients had a SN hyperechogenicity, in all it was unilateral, confirming previous results in healthy subjects. Bilateral SN hyperechogenicity indicates IPD and normal SN echogenicity indicates NED. In 30% of patients TCS does not distinguish between IPD and NED. Data further support the assumption that bilateral SN hyperechogenicity is specific for IPD.

Keywords: Transcranial sonographyParkinson's diseasesubstantia nigra hyperechogenicity.

Copyright information

© Springer-Verlag Wien 2002

Authors and Affiliations

  • U. Walter
    • 1
  • M. Wittstock
    • 1
  • R. Benecke
    • 1
  • D. Dressler
    • 1
  1. 1.Department of Neurology, Rostock University, Rostock, Federal Republic of GermanyDE