Journal of Neural Transmission

, Volume 108, Issue 10, pp 1181-1196

First online:

A behavioural pattern analysis of hypoglutamatergic mice – effects of four different antipsychotic agents

  • M. NilssonAffiliated withDepartment of Pharmacology, Institute of Physiology and Pharmacology, Göteborg University,
  • , S. WatersAffiliated withCarlsson Research AB, and
  • , N. WatersAffiliated withCarlsson Research AB, and
  • , A. CarlssonAffiliated withCarlsson Research AB, and
  • , M. L. CarlssonAffiliated withInstitute of Clinical Neuroscience, Neuropsychiatric Research Unit, Göteborg University, Göteborg, Sweden

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Summary.

In a hypoglutamatergic rodent model, we have observed certain behaviours that might have relevance for the cognitive impairments seen in autism and schizophrenia. Thus, hypoglutamatergic mice show defective habituation, impaired attention, a meagre behavioural repertoire and a general behavioural primitivization. The aim of the present study was to characterise and quantify changes in movement pattern in mice rendered hypoglutamatergic by means of MK-801 treatment, using an automated video tracking system. Further, the effects of four different antipsychotic drugs, the classical neuroleptic haloperidol, the atypical antipsychotic clozapine, the DA D2/5-HT2A antagonist risperidone and the selective 5-HT2A-receptor antagonist M100907, were compared with respect to effects on NMDA antagonist-induced movement pattern alterations.

We found that each receptor antagonist had a unique effect on the MK-801-induced behavioural primitivization. Haloperidol was unable to affect the monotonous behaviour induced by MK-801, while risperidone, clozapine and M100907 produced movement patterns of high intricacy.

Keywords: Schizophrenia autism cognition video tracking MK-801 mice.