Journal of Neural Transmission

, Volume 108, Issue 12, pp 1435–1443

Spatial memory deficit and neurodegeneration induced by the direct injection of okadaic acid into the hippocampus in rats

  • J. He
  • K. Yamada
  • L.-B. Zou
  • T. Nabeshima

DOI: 10.1007/s007020100018

Cite this article as:
He, J., Yamada, K., Zou, L. et al. J Neural Transm (2001) 108: 1435. doi:10.1007/s007020100018

Summary.

We investigated the effects of okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, on spatial memory and neuronal survival in rats. Rats were initially trained on a spatial memory task in an eight arm radial maze. Spatial reference and working memory was impaired 1 day after the unilateral microinjection of OA into the dorsal hippocampus. The impairment was transient, and had disappeared by the following day. In contrast, neurodegeneration induced by OA was persistent and extended to the contralateral side 13 days after the injection. These results suggest that OA causes spatial memory impairment and neurodegeneration when injected directly into the hippocampus. Our findings also indicate dissociation between memory impairment and neurodegeneration induced by OA.

Keywords: Okadaic acid, learning and memory, radial arm maze, neurodegeneration, synaptic plasticity.

Copyright information

© Springer-Verlag Wien 2001

Authors and Affiliations

  • J. He
    • 1
  • K. Yamada
    • 1
  • L.-B. Zou
    • 1
  • T. Nabeshima
    • 1
  1. 1.Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, JapanJP