Journal of Neural Transmission

, Volume 106, Issue 9, pp 943–948

Increased cerebrospinal fluid levels of substance P in patients with amyotrophic lateral sclerosis

  • T. Matsuishi
  • S. Nagamitsu
  • H. Shoji
  • M. Itoh
  • S. Takashima
  • T. Iwaki
  • N. Shida
  • Y. Yamashita
  • T. Sakai
  • H. Kato
Short Communication

DOI: 10.1007/s007020050214

Cite this article as:
Matsuishi, T., Nagamitsu, S., Shoji, H. et al. J Neural Transm (1999) 106: 943. doi:10.1007/s007020050214

Summary.

To clarify the mechanism of brain and spinal cord impairment in amyotrophic lateral sclerosis (ALS), we measured the cerebrospinal fluid (CSF) levels of substance P (SP) in 11 patients with sporadic ALS. Findings were compared with those obtained in controls and diseased controls. The CSF SP levels of patients with ALS, and particularly in patients with a disease duration of less than 2.5 years, were significantly higher than those in controls.

These findings strongly suggested that SP may play an important role in the pathophysiology of ALS.

Keywords: Substance P cerebrospinal fluid amyotrophic lateral sclerosis. 

Copyright information

© Springer-Verlag Wien 1999

Authors and Affiliations

  • T. Matsuishi
    • 1
  • S. Nagamitsu
    • 1
  • H. Shoji
    • 2
  • M. Itoh
    • 3
  • S. Takashima
    • 3
  • T. Iwaki
    • 4
  • N. Shida
    • 5
  • Y. Yamashita
    • 1
  • T. Sakai
    • 5
  • H. Kato
    • 1
  1. 1.Department of Pediatrics and Child Health, and
  2. 2.First Department (Neurology) of Internal Medicine, Kurume University School of Medicine, Fukuoka,
  3. 3.Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, NCNP, Tokyo,
  4. 4.Department of Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University, Fukuoka, and
  5. 5.Department of Neurology, National Chikugo Hospital, Fukuoka, JapanJP

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