Increased cerebrospinal fluid levels of substance P in patients with amyotrophic lateral sclerosis
- Cite this article as:
- Matsuishi, T., Nagamitsu, S., Shoji, H. et al. J Neural Transm (1999) 106: 943. doi:10.1007/s007020050214
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To clarify the mechanism of brain and spinal cord impairment in amyotrophic lateral sclerosis (ALS), we measured the cerebrospinal fluid (CSF) levels of substance P (SP) in 11 patients with sporadic ALS. Findings were compared with those obtained in controls and diseased controls. The CSF SP levels of patients with ALS, and particularly in patients with a disease duration of less than 2.5 years, were significantly higher than those in controls.
These findings strongly suggested that SP may play an important role in the pathophysiology of ALS.