Journal of Neural Transmission

, Volume 106, Issue 9, pp 883-888

First online:

Serum and cerebrospinal fluid concentrations of melatonin: a pilot study in healthy male volunteers

  • A. RousseauAffiliated withDepartment of Neuroscience and Locomotion, Division of Psychiatry, University Hospital, Linköping, and
  • , S. PetrénAffiliated withDepartment of Neuroscience and Locomotion, Division of Psychiatry, University Hospital, Linköping, and
  • , J. PlannthinAffiliated withDepartment of Neuroscience and Locomotion, Division of Psychiatry, University Hospital, Linköping, and
  • , T. EklundhAffiliated withDepartment of Clinical Neuroscience and Family Medicine, Psychiatry Section, Huddinge University Hospital, Huddinge, Sweden
  • , C. NordinAffiliated withDepartment of Neuroscience and Locomotion, Division of Psychiatry, University Hospital, Linköping, and

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Summary.

Melatonin was determined in serum and cerebrospinal fluid (CSF) obtained from 13 healthy males lumbar-punctured in the sitting position without preceding bed rest.

There was a significant correlation between the levels of melatonin in serum and the CSF.

The serum concentration was lower than that in the CSF, a finding that calls in question the theory that melatonin is mainly released from the pineal gland into the bloodstream.

In conclusion, serum levels of melatonin in healthy male volunteers, mirror the CSF concentrations when lumbar puncture is carried out using the described technique.

Keywords: Melatonin cerebrospinal fluid serum.