Abstract
There is wide variability in the reported prevalence rates of abnormal smell in Parkinson disease (PD). This study assessed the prevalence of abnormal smell, using the University of Pennsylvania Smell Identification Test (UPSIT), in 183 patients with PD with confirmed PET imaging evidence of nigrostriatal denervation. Impaired olfaction in this sample was nearly universal (97.8 %). Wide-ranging prior olfactory impairment estimates may reflect not only uncertainty regarding diagnostic classification, but also the use of inaccurate normative data and differences in olfactory tests used.
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Abbreviations
- PET:
-
Positron emission tomography
- PD:
-
Parkinson disease
- UPSIT:
-
University of Pennsylvania Smell Identification Test
- VMAT2:
-
Vesicular monoamine transporter type 2
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Acknowledgments
The authors thank all patients for their time commitment and research assistants, PET technologists, cyclotron operators, chemists, and Mrs. Haugen for their assistance with the study. This work was supported by the Michael J. Fox Foundation, Department of Veterans Affairs (Grant Number I01 RX000317) and the NIH (Grant Numbers P01 NS015655, RO1 NS070856 and P50 NS091856).
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Haugen, J., Müller, M.L.T.M., Kotagal, V. et al. Prevalence of impaired odor identification in Parkinson disease with imaging evidence of nigrostriatal denervation. J Neural Transm 123, 421–424 (2016). https://doi.org/10.1007/s00702-016-1524-7
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DOI: https://doi.org/10.1007/s00702-016-1524-7