Journal of Neural Transmission

, Volume 121, Issue 7, pp 717–724

Association of MDR1 gene C3435T polymorphism with childhood intractable epilepsy: a meta-analysis

Translational Neurosciences - Original Article

DOI: 10.1007/s00702-014-1169-3

Cite this article as:
Sun, G., Sun, X. & Guan, L. J Neural Transm (2014) 121: 717. doi:10.1007/s00702-014-1169-3


Drug-resistant epilepsy is also referred to as intractable, medically refractory, or pharmacoresistant epilepsy. Approximately, one-third of patients with epilepsy have recurrent seizures despite therapy. Multidrug resistance 1 (MDR1) gene may play a role in drug-resistance in epilepsy. To assess the association between MDR1 C3435T polymorphism and the response to anticonvulsants in childhood intractable epilepsy, we conducted a systematic review and meta-analysis. Studies were obtained from the electronic database of PubMed, Medline, Embase and CNKI up to September 2013. All the case–control association researches evaluating the role of MDR1 C3435T polymorphism in childhood epilepsy to antiepileptic drugs were identified. The odds ratios (ORs) with 95 % confidence intervals (CIs) were calculated for comparisons of the alleles and genotypes with co-dominant (C/C vs. T/T, C/T vs. T/T), dominant (C/C + C/T vs. T/T), and recessive (C/C vs. C/T + T/T) models in overall and in ethnicity subgroups to measure the strength of genetic association. A total of 8 related studies, including 634 drug-resistant patients, 615 drug-responsive patients and 1,052 healthy controls were pooled in this meta-analysis. The allelic association of MDR1 C3435T with risk of drug-resistance was not significant (OR 1.03, 95 % CI 0.87–1.22, P = 0.73; OR 1.00, 95 % CI 0.86–1.16, P = 0.98) in overall and in the subgroup analysis by ethnicity (Asian: OR 0.95, 95 % CI 0.77–1.18, P = 0.67; Caucasian: OR 1.18, 95 % CI 0.89–1.57, P = 0.25). Neither association was found in other genetic models. Our results did not show a significant association between MDR1 C3435T polymorphism and response to anticonvulsant drugs, suggesting that this polymorphism may not be a risk factor to childhood intractable epilepsy.


EpilepsyMultidrug resistance 1 geneC3435TPolymorphismMeta-analysis

Copyright information

© Springer-Verlag Wien 2014

Authors and Affiliations

  1. 1.Department of PediatricsThe First Affiliated Hospital of China Medical UniversityShenyangChina