Journal of Neural Transmission

, Volume 121, Issue 4, pp 451–455

Change in electrodermal activity after acute tryptophan depletion associated with aggression in young people with attention deficit hyperactivity disorder (ADHD)

  • G. G. von Polier
  • C. S. Biskup
  • W. F. Kötting
  • S. Bubenzer
  • K. Helmbold
  • A. Eisert
  • T. J. Gaber
  • F. D. Zepf
Psychiatry and Preclinical Psychiatric Studies - Short communication

DOI: 10.1007/s00702-013-1119-5

Cite this article as:
von Polier, G.G., Biskup, C.S., Kötting, W.F. et al. J Neural Transm (2014) 121: 451. doi:10.1007/s00702-013-1119-5

Abstract

We investigated the impact of acute tryptophan depletion (ATD) and reduced brain serotonin synthesis on physiological arousal in 15 young people with ADHD participating in an aggression-inducing game. ATD was not associated with altered physiological arousal, as indexed by electrodermal activity (EDA). Baseline aggression was negatively correlated with the mean ATD effect on EDA. In accordance with the low arousal theory related to aggressive behavior, subjects with reduced physiological responsiveness/lower electrodermal reactivity to ATD tended to display elevated externalizing behavior.

Keywords

SerotoninADHDElectrodermal activityPhysiological arousalAggression

Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  • G. G. von Polier
    • 1
    • 2
  • C. S. Biskup
    • 1
    • 3
  • W. F. Kötting
    • 1
    • 3
  • S. Bubenzer
    • 1
    • 3
  • K. Helmbold
    • 1
    • 3
  • A. Eisert
    • 4
  • T. J. Gaber
    • 1
    • 3
  • F. D. Zepf
    • 1
    • 3
    • 5
  1. 1.Translational Neuroscience in Psychiatry and Neurology, Clinic for Child and Adolescent Psychiatry, Psychosomatics and PsychotherapyRWTH Aachen UniversityAachenGermany
  2. 2.Child Neuropsychology Section, Clinic for Child and Adolescent Psychiatry, Psychosomatics and PsychotherapyRWTH Aachen UniversityAachenGermany
  3. 3.JARA Translational Brain MedicineAachen, JülichGermany
  4. 4.Department of PharmacyRWTH Aachen UniversityAachenGermany
  5. 5.Jülich Research CenterInstitute for Neuroscience and MedicineJülichGermany