Journal of Neural Transmission

, Volume 121, Issue 4, pp 399–407

Impaired motor speech performance in Huntington’s disease

  • Sabine Skodda
  • Uwe Schlegel
  • Rainer Hoffmann
  • Carsten Saft
Neurology and Preclinical Neurological Studies - Original Article

DOI: 10.1007/s00702-013-1115-9

Cite this article as:
Skodda, S., Schlegel, U., Hoffmann, R. et al. J Neural Transm (2014) 121: 399. doi:10.1007/s00702-013-1115-9

Abstract

Dysarthria is a common symptom of Huntington’s disease and has been reported, besides other features, to be characterized by alterations of speech rate and regularity. However, data on the specific pattern of motor speech impairment and their relationship to other motor and neuropsychological symptoms are sparse. Therefore, the aim of the present study was to describe and objectively analyse different speech parameters with special emphasis on the aspect of speech timing of connected speech and non-speech verbal utterances. 21 patients with manifest Huntington’s disease and 21 age- and gender-matched healthy controls had to perform a reading task and several syllable repetition tasks. Computerized acoustic analysis of different variables for the measurement of speech rate and regularity generated a typical pattern of impaired motor speech performance with a reduction of speech rate, an increase of pauses and a marked disability to steadily repeat single syllables. Abnormalities of speech parameters were more pronounced in the subgroup of patients with Huntington’s disease receiving antidopaminergic medication, but were also present in the drug-naïve patients. Speech rate related to connected speech and parameters of syllable repetition showed correlations to overall motor impairment, capacity of tapping in a quantitative motor assessment and some score of cognitive function. After these preliminary data, further investigations on patients in different stages of disease are warranted to survey if the analysis of speech and non-speech verbal utterances might be a helpful additional tool for the monitoring of functional disability in Huntington’s disease.

Keywords

Huntington’s disease Dysarthria Motor speech performance Speech timing Tapping 

Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  • Sabine Skodda
    • 1
  • Uwe Schlegel
    • 1
  • Rainer Hoffmann
    • 2
  • Carsten Saft
    • 2
  1. 1.Department of Neurology, KnappschaftskrankenhausRuhr-University of BochumBochumGermany
  2. 2.Department of Neurology, Huntington-Centre NRW, St. Josef HospitalRuhr-University of BochumBochumGermany