Neurology and Preclinical Neurological Studies - Short communication

Journal of Neural Transmission

, Volume 121, Issue 2, pp 147-151

Levodopa inhibits habit-learning in Parkinson’s disease

  • Hannah FuhrerAffiliated withDepartment of Neurology, Charité-University Medicine Berlin, Campus Virchow KlinikumDepartment of Neurology, University of Freiburg
  • , Andreas KupschAffiliated withDepartment of Neurology, Charité-University Medicine Berlin, Campus Virchow KlinikumDepartment of Neurology and Stereotactic Neurosurgery, Otto-von-Guericke-University Magdeburg
  • , Thomas D. HälbigAffiliated withDepartment of Neurology, Charité-University Medicine Berlin, Campus Virchow Klinikum
  • , Ute A. KoppAffiliated withDepartment of Neurology, Charité-University Medicine Berlin, Campus Virchow Klinikum
  • , Peter SchererAffiliated withDepartment of Neurology, Charité-University Medicine Berlin, Campus Virchow Klinikum
  • , Doreen GruberAffiliated withDepartment of Neurology, Charité-University Medicine Berlin, Campus Virchow KlinikumMovement Disorders Clinic Email author 

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Abstract

Mixed dopaminergic medication, comprising dopamine agonists and levodopa, may affect habit-learning in patients with Parkinson’s disease (PD). However, the specific impact of levodopa on this effect is unknown. We assessed habit-learning in 20 non-demented PD-patients both with and without levodopa. We observed intact habit-learning in PD-patients OFF-medication. In contrast, the administration of 200 mg of levodopa impaired habit-learning. We conclude that potential deficits in habit-learning in PD may be attributed to the intake of levodopa.

Keywords

Parkinson’s disease Habit-learning Levodopa Cognition