Levodopa inhibits habit-learning in Parkinson’s disease
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- Fuhrer, H., Kupsch, A., Hälbig, T.D. et al. J Neural Transm (2014) 121: 147. doi:10.1007/s00702-013-1081-2
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Mixed dopaminergic medication, comprising dopamine agonists and levodopa, may affect habit-learning in patients with Parkinson’s disease (PD). However, the specific impact of levodopa on this effect is unknown. We assessed habit-learning in 20 non-demented PD-patients both with and without levodopa. We observed intact habit-learning in PD-patients OFF-medication. In contrast, the administration of 200 mg of levodopa impaired habit-learning. We conclude that potential deficits in habit-learning in PD may be attributed to the intake of levodopa.