Journal of Neural Transmission

, Volume 121, Issue 2, pp 147–151

Levodopa inhibits habit-learning in Parkinson’s disease

  • Hannah Fuhrer
  • Andreas Kupsch
  • Thomas D. Hälbig
  • Ute A. Kopp
  • Peter Scherer
  • Doreen Gruber
Neurology and Preclinical Neurological Studies - Short communication

DOI: 10.1007/s00702-013-1081-2

Cite this article as:
Fuhrer, H., Kupsch, A., Hälbig, T.D. et al. J Neural Transm (2014) 121: 147. doi:10.1007/s00702-013-1081-2

Abstract

Mixed dopaminergic medication, comprising dopamine agonists and levodopa, may affect habit-learning in patients with Parkinson’s disease (PD). However, the specific impact of levodopa on this effect is unknown. We assessed habit-learning in 20 non-demented PD-patients both with and without levodopa. We observed intact habit-learning in PD-patients OFF-medication. In contrast, the administration of 200 mg of levodopa impaired habit-learning. We conclude that potential deficits in habit-learning in PD may be attributed to the intake of levodopa.

Keywords

Parkinson’s diseaseHabit-learningLevodopaCognition

Supplementary material

702_2013_1081_MOESM1_ESM.docx (326 kb)
Supplementary material 1 (DOCX 325 kb)

Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  • Hannah Fuhrer
    • 1
    • 2
  • Andreas Kupsch
    • 1
    • 3
  • Thomas D. Hälbig
    • 1
  • Ute A. Kopp
    • 1
  • Peter Scherer
    • 1
  • Doreen Gruber
    • 1
    • 4
  1. 1.Department of NeurologyCharité-University Medicine Berlin, Campus Virchow KlinikumBerlinGermany
  2. 2.Department of NeurologyUniversity of FreiburgFreiburgGermany
  3. 3.Department of Neurology and Stereotactic NeurosurgeryOtto-von-Guericke-University MagdeburgMagdeburgGermany
  4. 4.Movement Disorders ClinicBeelitz-HeilstättenGermany