Neurology and Preclinical Neurological Studies - Short communication

Journal of Neural Transmission

, Volume 120, Issue 10, pp 1441-1445

First online:

A preliminary method development study to identify potential stroke biomarkers in plasma using multiple chromatographies with nanoLC-ESIMS detection

  • Phanichand KodaliAffiliated withDepartment of Chemistry, University of Cincinnati
  • , Julio A. Landero-FigueroaAffiliated withDepartment of Chemistry, University of Cincinnati
  • , Joseph CarusoAffiliated withDepartment of Chemistry, University of Cincinnati Email author 
  • , Opeolu AdeoyeAffiliated withDepartment of Emergency Medicine, University of Cincinnati

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Abstract

Stroke is the leading cause of disability in the USA. Rapid, reliable diagnosis via a point-of-care blood test may facilitate earlier treatment to reduce disability. We have recently reported detailed methods of chromatographic separations of plasma samples coupled with nanoESI-ion trap a list of proteins which are viable candidates for further investigation as stroke biomarkers.

Keywords

Blood plasma Biomarkers HPLC Stroke