Journal of Neural Transmission

, Volume 119, Issue 12, pp 1491–1498

Association of functional COMT Val108/Met polymorphism with smoking cessation in a nicotine replacement therapy

  • Hongqiang Sun
  • Song Guo
  • Dafang Chen
  • Fude Yang
  • Yizhuang Zou
  • Xiaolan Di
  • Yanjun Cao
  • Thomas Kosten
  • Lin Lu
  • Xiang Yang Zhang
Basic Neurosciences, Genetics and Immunology - Original Article

DOI: 10.1007/s00702-012-0841-8

Cite this article as:
Sun, H., Guo, S., Chen, D. et al. J Neural Transm (2012) 119: 1491. doi:10.1007/s00702-012-0841-8

Abstract

Nicotine replacement treatment (NRT) can be efficacious for smoking cessation, but used by only a minority of smokers in China. Pharmacogenetic matching may improve treatment outcomes for NRT in subgroups of smokers. We evaluated the efficacy and safety of sublingual nicotine tablets (SNT) for smoking cessation and the association of catechol-O-methyltransferase (COMT) genotype with efficacy in this smoking cessation trial among Chinese smokers. We conducted a double-blind, placebo-controlled, 8-week trial of SNT with a follow-up at week 12 among 250 Chinese smokers. Efficacy and safety were evaluated at day 4 and weeks 2, 4, 6, 8, and 12. Abstinence was biochemically verified by exhaled carbon monoxide (CO) and urine cotinine. The COMT Val108Met genotype was determined as a restriction fragment length polymorphism. Our results showed that the success rates for complete abstinence were greater for active versus placebo treatments at 8 weeks (48 vs. 17 %) and 12 weeks (52 vs. 19 %) (both p < 0.0001). Craving was significantly reduced from week 2 on active treatment compared to placebo. Adverse events were mild and tolerable. We found a genotype by treatment interaction at 12 weeks with greater abstinence rates in the COMT Val/Val (50 vs. 15 %) than the Met/Val + Met/Met genotypes (46 vs. 25 %). We found that SNT significantly increased smoking abstinence, reduced craving and was well tolerated, and the COMT Val/Val genotype was associated with a greater improvement in smoking cessation.

Keywords

Pharmacogenetics COMT Nicotine dependence Smoking Dopamine 

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Hongqiang Sun
    • 1
    • 2
  • Song Guo
    • 3
    • 4
  • Dafang Chen
    • 5
  • Fude Yang
    • 1
  • Yizhuang Zou
    • 1
  • Xiaolan Di
    • 1
  • Yanjun Cao
    • 1
  • Thomas Kosten
    • 6
  • Lin Lu
    • 2
  • Xiang Yang Zhang
    • 1
    • 6
    • 7
  1. 1.Beijing Hui-Long-Guan HospitalBeijingChina
  2. 2.The National Institute on Drug DependencePeking UniversityBeijingChina
  3. 3.National Drug Abuse Treatment CenterBeijing Anding Hospital Affiliated Capital University of Medical SciencesBeijingChina
  4. 4.Addiction Medicine DepartmentInstitute of Mental HealthSingaporeSingapore
  5. 5.Department of Epidemiology and Biostatistics, School of Public HealthPeking UniversityBeijingChina
  6. 6.Department of Psychiatry and Behavioral SciencesBaylor College of MedicineHoustonUSA
  7. 7.VA Medical CenterHoustonUSA

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